Nonspecific intraventricular conduction delay predicts the prognosis of dilated cardiomyopathy

作者全名："Yuan, Yong; Yang, Kai; Liu, Qianjun; Song, Weixiang; Jin, Dongsheng; Zhao, Shihua"

作者地址："[Yuan, Yong; Yang, Kai; Zhao, Shihua] Chinese Acad Med Sci & Peking Union Med Coll, Cardiovasc Imaging & Intervent Ctr, Dept Magnet Resonance Imaging, State Key Lab Cardiovasc Dis,Natl Ctr Cardiovasc D, Beijing 100037, Peoples R China; [Yuan, Yong; Jin, Dongsheng] Nanjing Med Univ, Dept Diagnost Imaging, Geriatr Hosp, Nanjing 210024, Peoples R China; [Liu, Qianjun] Fudan Univ, Dept Cardiol, Huadong Hosp, Shanghai 200040, Peoples R China; [Song, Weixiang] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 2, Chongqing 400010, Peoples R China"

通信作者："Zhao, SH (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Cardiovasc Imaging & Intervent Ctr, Dept Magnet Resonance Imaging, State Key Lab Cardiovasc Dis,Natl Ctr Cardiovasc D, Beijing 100037, Peoples R China.; Jin, DS (通讯作者)，Nanjing Med Univ, Dept Diagnost Imaging, Geriatr Hosp, Nanjing 210024, Peoples R China."

来源：BMC CARDIOVASCULAR DISORDERS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001050365500005

JCR分区：Q3

影响因子：2

年份：2023

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Prognosis; Dilated cardiomyopathy; Bundle branch block; Magnetic resonance imaging

摘要："PurposeLeft bundle branch block (LBBB) has been confirmed to be independently associated with adverse outcomes in dilated cardiomyopathy (DCM). However, prognostic data on nonspecific intraventricular conduction delay (NSIVCD) are still limited and conflicting. We aimed to evaluate the prognosis of DCM with NSIVCD.MethodsA total of 548 DCM patients who underwent cardiovascular magnetic resonance imaging (CMR) from January 2016 to December 2017 were consecutively enrolled. The cohort was divided into four groups: 87 with LBBB, 27 with RBBB, 61 with NSIVCD, and 373 without intraventricular conduction delay (IVCD). After a median follow-up of 58 months (interquartile range: 47-65), 123 patients reached the composite endpoints, which included cardiovascular death, heart transplantation, and malignant arrhythmias. The associations between different patterns of IVCD and the outcomes of DCM were analysed by Kaplan-Meier analysis and Cox proportional hazards regression analysis.ResultsOf 548 DCM patients, there were 398 males (72.6%), and the average age was 46 & PLUSMN; 15 years, ranging from 18 to 76 years. In Kaplan-Meier analysis, patients with NSIVCD and LBBB showed higher event rates than patients without IVCD, while RBBB patients did not. By multivariate Cox regression analysis, LBBB, NSIVCD, NYHA class, left ventricular ejection fraction (LVEF), indexed left ventricular end-diastolic diameter (LVEDDI), percentage of late gadolinium enhancement mass (LGE%), and global longitudinal strain (GLS) were found to be independently associated with the outcomes of DCM.ConclusionsIn addition to LBBB, NSIVCD was an unfavourable prognostic marker in patients with DCM, independent of LVEDDI, NYHA class, LVEF, LGE%, and GLS."

基金机构："National Natural Science Foundation of China [81930044]; National Key Research and Development Program of China [2021YFF0501404, 2021YFF0501400]"

基金资助正文："This study was co-funded by the National Natural Science Foundation of China (No. 81930044) and the National Key Research and Development Program of China (No. 2021YFF0501404, 2021YFF0501400).& nbsp;"