"Effects of NAD plus precursors on blood pressure, C-reactive protein concentration and carotid intima-media thickness: A meta-analysis of randomized controlled trials"

作者全名："Lei, Langhuan; Zhang, Xiaoli; Lin, Jiali; Liang, Qiuyu; Sohouli, Mohammad Hassan; Magalhaes, Elma Izze da Silva; Fatahi, Somaye; Yang, Lihua; Xu, Wanting; Wang, Xingyong; Li, Wei; Yang, Jianrong"

作者地址："[Lei, Langhuan; Lin, Jiali; Liang, Qiuyu; Li, Wei; Yang, Jianrong] Guangxi Zhuang Autonomous Reg Peoples Hosp, Res Ctr Hlth Management, Nanning 530016, Peoples R China; [Lei, Langhuan; Lin, Jiali; Liang, Qiuyu; Li, Wei; Yang, Jianrong] Guangxi Acad Med Sci, Nanning 530016, Peoples R China; [Zhang, Xiaoli] Third Mil Med Univ, Coll Pharm, Dept Clin Hematol, Chongqing, Peoples R China; [Sohouli, Mohammad Hassan; Fatahi, Somaye] Shahid Beheshti Univ Med Sci, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Student Res Comm, Tehran, Iran; [Magalhaes, Elma Izze da Silva] Univ Fed Maranhao, Postgrad Programme Collect Hlth, Sao Luis, Brazil; [Yang, Lihua] Maternal & Child Hlth Hosp Guangxi Zhuang Autonomo, Nanning, Peoples R China; [Xu, Wanting] Chengdu Second Peoples Hosp, Pediat Dept, Chengdu, Peoples R China; [Wang, Xingyong] Chongqing Med Univ, Childrens Hosp, Dept Crit Care Med, Chongqing, Peoples R China; [Li, Wei] Guangxi Zhuang Autonomous Reg Peoples Hosp, Dept Hlth Management, Nanning 530016, Peoples R China"

通信作者："Li, W; Yang, JR (通讯作者)，Guangxi Zhuang Autonomous Reg Peoples Hosp, Res Ctr Hlth Management, Nanning 530016, Peoples R China.; Li, W; Yang, JR (通讯作者)，Guangxi Acad Med Sci, Nanning 530016, Peoples R China.; Li, W (通讯作者)，Guangxi Zhuang Autonomous Reg Peoples Hosp, Dept Hlth Management, Nanning 530016, Peoples R China."

来源：EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001050508100001

JCR分区：Q1

影响因子：4.4

年份：2023

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期号：　

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文献类型：Article; Early Access

关键词：blood pressure; CIMT; CRP; meta-analysis; NAD plus precursor; niacin

摘要："BackgroundThere are contradictory effects regarding the effect of NAD+ precursor on blood pressure and inflammation. In order to obtain a better viewpoint from them, this study aimed to comprehensively investigate the effects of NAD+ precursor supplementation on blood pressure, C-reactive protein (CRP) and carotid intima-media thickness (CIMT). MethodsPubMed/MEDLINE, Web of Science, SCOPUS and Embase databases were searched using standard keywords to identify all controlled trials investigating the effects of NAD+ precursor on blood pressure, CRP and CIMT. Pooled weighted mean difference (WMD) and 95% confidence intervals (95% CI) were achieved by random-effects model analysis for the best estimation of outcomes. ResultsTwenty-nine articles (with 8664 participants) were included in this article. Results from meta-analyses of RCTs from random-effects models indicated a significant reduction in systolic (SBP) (weighted mean difference (WMD): -2.54 mmHg, p < .001) and diastolic blood pressure (DBP) (WMD: -2.15 mmHg, p < .001), as well as in CRP (WMD: -.93 mg/L, 95% CI -1.47 to -.40, p < .001) concentrations and CIMT (WMD: -.01 mm, 95% CI -.02 to -.00, p = .005) with the NAD+ precursors supplementation compared with the control group. In addition, a greater effect of supplementation with NAD+ precursors in reducing blood pressure (BP) were observed with the highest dose (& GE;2 g) and duration of the intervention (>12 weeks), as well as with NA supplementation when compared to NE. ConclusionsOverall, these findings suggest that NAD+ precursor supplementation might have a beneficial effect on cardiovascular risk factors such as BP, CRP concentration and CIMT."

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