Survival impact of bowel resection in patients with FIGO stage II-IV ovarian cancer
作者全名:"Wang, Qing-miao; Xiao, Yao; Liu, Yue-xi; Wei, Xing; Gu, Qiu-ying; Hua, Linghu; Liu, Bing"
作者地址:"[Wang, Qing-miao; Xiao, Yao; Liu, Yue-xi; Wei, Xing; Gu, Qiu-ying; Hua, Linghu] Chongqing Med Univ, Affiliated Hosp 1, Dept Gynecol, Chongqing 400016, Peoples R China; [Liu, Bing] Chongqing Med Univ, Affiliated Hosp 1, Dept Pathol, Chongqing 400016, Peoples R China"
通信作者:"Hua, LH (通讯作者),Chongqing Med Univ, Affiliated Hosp 1, Dept Gynecol, Chongqing 400016, Peoples R China.; Liu, B (通讯作者),Chongqing Med Univ, Affiliated Hosp 1, Dept Pathol, Chongqing 400016, Peoples R China."
来源:JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
ESI学科分类:CLINICAL MEDICINE
WOS号:WOS:001050727200001
JCR分区:Q3
影响因子:2.7
年份:2023
卷号:
期号:
开始页:
结束页:
文献类型:Article; Early Access
关键词:Ovarian cancer; Cytoreductive surgery; Bowel resection; Progression-free survival
摘要:"IntroductionTo compare the effect of bowel resection vs stripping on the clinical outcomes of patients with FIGO II-IV ovarian cancer.MethodsWe retrospectively analyzed patients with FIGO II-IV ovarian cancer who suffered from bowel involvement and underwent cytoreductive surgery between January 2014 and March 2022. Patients' survival was compared by Kaplan-Meier survival analysis and Cox proportional hazards models.ResultsFour hundred and twelve patients were included. 48 patients underwent bowel resection (BR), and 364 patients underwent bowel tumor stripping (BTS). The BR group had longer operative duration, hospital stay, time to post-operative chemotherapy, and more intraoperative bleeding. The median PFS was 37 months (95% CI 12-62) in BTS compared to 25 months (95% CI 10-40) in BR among patients who achieved R0 resection (p = 0.590). Among those with R1 resection, the median PFS in BST was 23 months (95% CI 16-30) and that in BR was 15 months (95% CI 12-18, p = 0.136); moreover, a favorable median PFS was observed in BTS with residual bowel lesions (23 months, 95% CI 14-32), compared to BR (15 months, 95% CI 12-18, p = 0.144). Multivariate analysis indicated that FIGO stage, PCI, cytoreduction time and residual lesions were independent prognostic factors of PFS.ConclusionFor patients with FIGO stage II-IV ovarian cancer with bowel implicated, bowel resection is necessary to achieve complete removal to improve the survival. If complete resection was judged unfeasible, cautious decision of bowel resection is required. Neoadjuvant chemotherapy might reduce the ratio of bowel resection for some with mesenteric involvement."
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