Rational use of drugs to alleviate adverse outcomes caused by COVID-19 quarantine in women with intrahepatic cholestasis of pregnancy

作者全名："Cai, Qin-Yu; Li, Xia; Yang, Yin; Luo, Xin; Luo, Shu-Juan; Xiong, Jing; He, Zong-Yan; Chen, Yuan; Mou, Yi-Wei; Hu, Ji-Yuan; Yang, Shu; Lan, Xia; Liu, Tai-Hang"

作者地址："[Cai, Qin-Yu; Li, Xia; He, Zong-Yan; Chen, Yuan; Mou, Yi-Wei; Hu, Ji-Yuan; Yang, Shu; Liu, Tai-Hang] Chongqing Med Univ, Sch Basic Med, Dept Bioinformat, Chongqing, Peoples R China; [Cai, Qin-Yu; Li, Xia; Luo, Xin; He, Zong-Yan; Chen, Yuan; Mou, Yi-Wei; Hu, Ji-Yuan; Yang, Shu; Liu, Tai-Hang] Minist Educ, Joint Int Res Lab Reprod & Dev, Chongqing, Peoples R China; [Yang, Yin] Chongqing Med Univ, Women & Childrens Hosp, Dept Infect Controlling Sect, Chongqing, Peoples R China; [Luo, Xin] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet, Chongqing, Peoples R China; [Luo, Shu-Juan; Xiong, Jing; Lan, Xia] Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Chongqing, Peoples R China"

通信作者："Liu, TH (通讯作者)，Chongqing Med Univ, Sch Basic Med, Dept Bioinformat, Chongqing, Peoples R China.; Liu, TH (通讯作者)，Minist Educ, Joint Int Res Lab Reprod & Dev, Chongqing, Peoples R China.; Lan, X (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Chongqing, Peoples R China."

来源：FRONTIERS IN MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001050949800001

JCR分区：Q1

影响因子：3.1

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：ICP; COVID-19; home quarantine; ursodeoxycholic acid; pregnancy outcome; public health

摘要："PurposeThis study aimed to investigate the impacts of home quarantine on pregnancy outcomes of women with intrahepatic cholestasis of pregnancy (ICP) during the COVID-19 outbreak and whether the rational use of drugs will change these impacts. MethodsThis multi-center study was conducted to compare the pregnancy outcomes in women with ICP between the home quarantine group and the non-home quarantine group in southwest China. Propensity score matching was performed to confirm the pregnancy outcomes of the medication group and the non-medication group in women with ICP during the epidemic period. ResultsA total of 3,161 women with ICP were enrolled in this study, including 816 in the home quarantine group and 2,345 in the non-home quarantine group. Women with ICP in the home quarantine group had worse pregnancy outcomes, such as a growing risk of gestational diabetes mellitus A1, fetal growth restriction, pre-eclampsia, preterm delivery, and even stillbirth. Drug therapy could alleviate some adverse pregnancy outcomes caused by home quarantine, including pre-eclampsia, preterm delivery, and meconium-stained amniotic fluid. ConclusionCOVID-19 quarantine would increase the incidence of ICP and lead to adverse pregnancy outcomes in women with ICP. The rational use of drugs reduced some obstetrical complications and improved partial pregnancy outcomes. Our findings suggested that the government and hospitals should enhance their management and life guidance for women with ICP and speed up developing home quarantine guidelines."

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