A resting-state electroencephalographic microstates study in depressed adolescents with non-suicidal self-injury

作者全名："Hu, Jin-hui; Zhou, Dong-dong; Ma, Lin-li; Zhao, Lin; He, Xiao-Qing; Peng, Xin-yu; Chen, Ran; Chen, Wan-Jun; Jiang, Zheng-Hao; Ran, Liu-yi; Liu, Xin-Yi; Tao, Wan-Qing; Yuan, Ke; Wang, Wo"

作者地址："[Hu, Jin-hui; Zhou, Dong-dong; He, Xiao-Qing; Chen, Ran; Jiang, Zheng-Hao; Ran, Liu-yi; Liu, Xin-Yi; Tao, Wan-Qing; Yuan, Ke; Wang, Wo] Chongqing Med Univ, Univ Town Hosp, Mental Hlth Ctr, Chongqing, Peoples R China; [Ma, Lin-li; Zhao, Lin; Peng, Xin-yu; Chen, Wan-Jun] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China"

通信作者："Wang, W (通讯作者)，Chongqing Med Univ, Univ Town Hosp, Mental Hlth Ctr, Chongqing, Peoples R China."

来源：JOURNAL OF PSYCHIATRIC RESEARCH

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001051485900001

JCR分区：Q1

影响因子：3.7

年份：2023

卷号：165

期号：　

开始页：264

结束页：272

文献类型：Article

关键词：　

摘要："Neuroimaging studies have revealed abnormal brain activities in depressed teenagers who engage in non-suicidal self-injury (NSSI). We used resting-state electroencephalography (EEG) microstate analysis, which indicates the brief overlap of brain network activation for exploring the characteristics of large-scale cortical activities in depressed adolescents engaged with NSSI to clarify the underlying temporal mechanism. A modified k-means cluster algorithm was used to segment 64 channel resting-state EEG data into microstates. Data from 27 healthy adolescents, 37 adolescents with major depressive disorder (MDD), and 53 adolescents with both MDD and NSSI were examined in this study. The resting-state microstate parameters were compared among groups using the one-way ANOVA and Spearman correlation. Then the associations between significantly different microstate parameters and the depressive severity and self-harming data in the patient groups were further analyzed. The MDD group had higher contribution (p < 0.01), occurrence (p < 0.01) of microstate A, and higher microstate E-*A transition (p < 0.05) than the HC and the NSSI group. The MDD group showed a distinctly longer duration (p < 0.05) of microstate A and microstate A-*C transition than the HC. The transition probability from B to C was increased in the NSSI group compared to the HC. In the MDD group, the HAMD correlated with the duration of microstate A (Spearman's rho = 0.34, p = 0.044), as the PHQ-9 correlated with its occurrence (Spearman's rho = 0.37, p = 0.028). This research revealed that whereas depressive adolescents with NSSI and MDD displayed similar patterns with healthy controls in EEG microstate, the MDD group did not. Additionally, the non-random transition from microstate E-*A may protect against recent self-harm in adolescents with MDD."

基金机构："Science and Technology Bureau of Chongqing [2022NSCQ-MSX0292, cstc2020jcyj-msxmX0222]; Chongqing Medical Scientific Research Youth Program [2023QNXM050]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0180]"

基金资助正文："This work was supported by grants from the Science and Technology Bureau of Chongqing (2022NSCQ-MSX0292; cstc2020jcyj-msxmX0222) and the Chongqing Medical Scientific Research Youth Program (2023QNXM050), the Program for Youth Innovation in Future Medicine, Chongqing Medical University (W0180). The authors thank all the editors and reviewers who participated in the review."