Mannosylated polydopamine nanoparticles alleviate radiation- induced pulmonary fibrosis by targeting M2 macrophages and inhibiting the TGF-β1/Smad3 signaling pathway

作者全名："Shen, Li; Fu, Shiyan; Chen, Yonglai; Li, Wenrun; Liu, Suiyi; Li, Zhi; Li, Jie; Li, Yong; Ran, Yonghong; Zhang, Jing; Qiao, Lu; Hao, Yuhui"

作者地址："[Shen, Li; Fu, Shiyan; Chen, Yonglai; Li, Wenrun; Liu, Suiyi; Li, Jie; Li, Yong; Ran, Yonghong; Zhang, Jing; Qiao, Lu; Hao, Yuhui] Army Med Univ, Coll Mil Prevent Med, Chongqing 400038, Peoples R China; [Li, Zhi] Gen Hosp Cent Theater Command, Med Serv Training Ctr, Wuhan 430070, Peoples R China; [Hao, Yuhui] Army Med Univ, Chongqing Engn Res Ctr Nanomed, State Key Lab Trauma Burns & Combined Injury, Inst Combined Injury,Coll Prevent Med, 30 Gaotanyan St, Chongqing 400038, Peoples R China"

通信作者："Hao, YH (通讯作者)，Army Med Univ, Chongqing Engn Res Ctr Nanomed, State Key Lab Trauma Burns & Combined Injury, Inst Combined Injury,Coll Prevent Med, 30 Gaotanyan St, Chongqing 400038, Peoples R China."

来源：COLLOIDS AND SURFACES B-BIOINTERFACES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001053393300001

JCR分区：Q1

影响因子：5.4

年份：2023

卷号：227

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Radiation-induced pulmonary fibrosis; Mannosylated polydopamine nanoparticles; M2 macrophages; Mucus penetration; TGF-beta 1

摘要："Radiation-induced pulmonary fibrosis (RIPF), one type of pulmonary interstitial diseases, is frequently observed following radiation therapy for chest cancer or accidental radiation exposure. Current treatments against RIPF frequently fail to target lung effectively and the inhalation therapy is hard to penetrate airway mucus. Therefore, this study synthesized mannosylated polydopamine nanoparticles (MPDA NPs) through one-pot method to treat RIPF. Mannose was devised to target M2 macrophages in the lung through CD 206 receptor. MPDA NPs showed higher efficiency of penetrating mucus, cellular uptake and ROS-scavenging than original polydopamine nano-particles (PDA NPs) in vitro. In RIPF mice, aerosol administration of MPDA NPs significantly alleviated the inflammatory, collagen deposition and fibrosis. The western blot analysis demonstrated that MPDA NPs inhibited TGF-beta 1/Smad3 signaling pathway against pulmonary fibrosis. Taken together this study provide a novel M2 macrophages-targeting nanodrugs through aerosol delivery for the prevention and targeted treatment for RIPF."

基金机构：Natural Science Foundation of Chongqing Province of China; [2022NSCQ-MSX4675]

基金资助正文：<B>Acknowledgements</B> This work was supported by the Natural Science Foundation of Chongqing Province of China (Grant No. 2022NSCQ-MSX4675) .