Exploring the regulatory role of lncRNA in cancer immunity

作者全名："Zhan, Dan-ting; Xian, Hong-chun"

作者地址："[Zhan, Dan-ting] Southwest Med Univ, Affiliated Stomatol Hosp, Dept Prosthodont, Luzhou, Peoples R China; [Xian, Hong-chun] Chongqing Med Univ, Affiliated Hosp 2, Dept Plast & Maxillofacial Surg, Chongqing, Peoples R China"

通信作者："Xian, HC (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Plast & Maxillofacial Surg, Chongqing, Peoples R China."

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001053901900001

JCR分区：Q2

影响因子：3.5

年份：2023

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：lncRNA; cancer immunity; cancer; immune evasion; tumor microenvironment

摘要："Imbalanced immune homeostasis in cancer microenvironment is a hallmark of cancer. Increasing evidence demonstrated that long non-coding RNAs (lncRNAs) have emerged as key regulatory molecules in directly blocking the cancer immunity cycle, apart from activating negative regulatory pathways for restraining tumor immunity. lncRNAs reshape the tumor microenvironment via the recruitment and activation of innate and adaptive lymphoid cells. In this review, we summarized the versatile mechanisms of lncRNAs implicated in cancer immunity cycle, including the inhibition of antitumor T cell activation, blockade of effector T cell recruitment, disruption of T cell homing, recruitment of immunosuppressive cells, and inducing an imbalance between antitumor effector cells (cytotoxic T lymphocytes, M1 macrophages, and T helper type 1 cells) versus immunosuppressive cells (M2 macrophages, T helper type 2 cells, myeloid derived suppressor cells, and regulatory T cells) that infiltrate in the tumor. As such, we would highlight the potential of lncRNAs as novel targets for immunotherapy."

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