"Evaluation of childhood developing <i>via</i> optical coherence tomography-angiography in Qamdo, Tibet, China: A prospective cross-sectional, school-based study"

作者全名："Sun, Ke-Xin; Xiang, Yong-Guo; Zhang, Tong; Yi, Sheng-Lan; Xia, Jiu-Yi; Yang, Xin; Zheng, Shi-Jie; Ji, Yan; Wan, Wen-Juan; Hu, Ke"

作者地址："[Sun, Ke-Xin; Xiang, Yong-Guo; Yi, Sheng-Lan; Xia, Jiu-Yi; Yang, Xin; Zheng, Shi-Jie; Ji, Yan; Wan, Wen-Juan; Hu, Ke] Chongqing Med Univ, Dept Ophthalmol, Affiliated Hosp 1, 1 Med Coll Rd, Chongqing 400016, Peoples R China; [Zhang, Tong] Chongqing Med Univ, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Hu, K (通讯作者)，Chongqing Med Univ, Dept Ophthalmol, Affiliated Hosp 1, 1 Med Coll Rd, Chongqing 400016, Peoples R China."

来源：WORLD JOURNAL OF CLINICAL CASES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001054089300008

JCR分区：Q3

影响因子：1

年份：2023

卷号：11

期号：23

开始页：5479

结束页：5493

文献类型：Article

关键词：Optical coherence tomography-angiography; Qamdo; Foveal avascular zone area; Vessel flow density; Teenager

摘要："BACKGROUND Optical coherence tomography angiography (OCTA) is a new and reliable machine used to evaluate retinal structure and macular perfusion in children. The use of OCTA under bad condition such as high altitude, low atmospheric oxygen, and low humidity, in children is rarely. AIM To quantify the macular micro-vasculature in healthy children of various ages using OCTA in Qamdo. METHODS Design: Prospective cross-sectional, school-based study. Three hundred and forty-seven normal students from 9 schools in 4 different areas in Qamdo were included. OCTA was performed on a 3 mm x 3 mm area centered on the macular region and macular cube 512 x 128 showed details in macular. Early treatment of diabetic retinopathy study Vessel Flow Density (VD) of the macular central vascular plexus density (CVD), inner vascular plexus density (IVD), full vascular plexus density (FVD), and the size of the foveal avascular zone (FAZ) were measured. All these results corrected by t/s = 3.382 x 0.01306 x (axial length-1.82). The differences were compared among various ages, sexes and living environments. RESULTS The mean FAZ area in all eyes was 0.27 mm(2) +/- 0.12 mm(2). The mean foveal thickness (MFT) in the macular cube was 227.64 mu m +/- 23.51 mu m. Compared with girls, boys had a lager FAZ (P = 0.0029). Among the different age groups, MFT (P < 0.001) and FVD (P < 0.0001), IVD (P < 0.0001), and CVD (P = 0.0050) increased with age. FAZ areas were not correlated with age (P = 0.8853) or others (MFT, area). CONCLUSION OCTA can use to evaluate macular perfusion in children. Our data bridge the gap between structural OCT and perfusion density in children in high altitude. Even though these were not a longitudinal study, it may provide us with hints about retina development during puberty and clinical implications of OCTA in children."

基金机构："National Natural Science Foundation of China [81870650, 81570832, 81300794]; Science and Technology Program Chongqing, China [2018GDRC008]"

基金资助正文："Supported by the National Natural Science Foundation of China, No. 81870650, No. 81570832, and No. 81300794; and Science and Technology Program Chongqing, China, No. 2018GDRC008."