Enhancement of sonodynamic treatment of ovarian cancer based on Pt-B-P ternary nanoparticles

作者全名："Yue, Song; He, Yirui; Wang, Min; Liu, Xiaozhu; Li, Xiaoying; Zhao, Binyi; Yi, Qiang; Li, Qinke; Yu, Qiubo; Yang, Zhu"

作者地址："[Yue, Song; Wang, Min; Yi, Qiang; Li, Qinke; Yang, Zhu] Chongqing Med Univ, Dept Gynecol & Obstet, Affiliated Hosp 2, Chongqing, Peoples R China; [He, Yirui] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing, Peoples R China; [Liu, Xiaozhu; Zhao, Binyi] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing, Peoples R China; [Li, Xiaoying] Peoples Hosp Yubei Dist Chongqing City, Oncol Dept, Chongqing, Peoples R China; [Yu, Qiubo] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China"

通信作者："Yang, Z (通讯作者)，Chongqing Med Univ, Dept Gynecol & Obstet, Affiliated Hosp 2, Chongqing, Peoples R China.; Yu, QB (通讯作者)，Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China."

来源：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001054329400001

JCR分区：Q2

影响因子：4.2

年份：2023

卷号：51

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Pt-B-P ternary particles; Ce6@PLGA nanoparticles; Sonodynamic therapy

摘要："Sonodynamic therapy (SDT) can noninvasively focus sound energy to deep tumor tissues and activate sonosensitizer (such as chlorin e6 (Ce6)) to produce antitumor effects. However, due to the hypoxic microenvironment of the tumor, the effect of sonodynamic therapy is limited. In this work, we successfully synthesized Platinum-Boron-Phosphorus ternary nanoparticles (Pt-B-P NPs) for the first time to efficiently catalyze the decomposition of hydrogen peroxide (H2O2) in tumor tissues to produce sufficient oxygen (O2) and improve the effect of sonodynamic treatment of ovarian cancer. In vitro studies, we found that compared with Platinum nanoparticles (Pt NPs), Pt-B-P NPs have the significantly increased ability to catalyze the decomposition of H2O2 to produce oxygen and thus the hypoxic environment of tumor cells could be improved efficiently. Meanwhile, the bio-distribution, therapeutic effect and bio-safety of Pt-B-P NPs in vivo were evaluated using BALB/c-nu mouse model of ovarian cancer and the desired result had been achieved.& COPY; 2023 Published by Elsevier Inc."

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