"Expression Profiles, Biological Functions and Clinical Significance of circRNAs in Pediatric Wilms Tumor"

作者全名：Tian Xiao-Mao; Xiang Bin; Liu Feng; Wei Guang-Hui

作者地址："[Tian Xiao-Mao; Xiang Bin; Liu Feng; Wei Guang-Hui] Chongqing Med Univ, Chongqing Key Lab Children Urogenital Dev & Tissu, China Int Sci & Technol Cooperat Base Child Dev &, Children Hosp,Dept Urol,Minist Educ Key Lab Child, Chongqing 400014, Peoples R China"

通信作者："Liu, F (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Children Urogenital Dev & Tissu, China Int Sci & Technol Cooperat Base Child Dev &, Children Hosp,Dept Urol,Minist Educ Key Lab Child, Chongqing 400014, Peoples R China."

来源：PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001054480300004

JCR分区：Q4

影响因子：0.2

年份：2023

卷号：50

期号：3

开始页：463

结束页：472

文献类型：Article

关键词：Wilms tumor; nephroblastoma; circRNA; ceRNA

摘要："Wilms tumor (WT) is the most common renal malignant tumor in children. The traditional clinical hierarchical diagnosis and treatment scheme cannot achieve the clinical goal of guiding precise risk stratification, especially in patients without high-risk factors. For example, patients with the same clinical phenotype and receiving the same treatment may have significant differences in prognosis, indicating that the disease is much more complex than previously recognized. This individual heterogeneity requires more in-depth molecular phenotypic studies to determine new markers and targets. Circular RNA (circRNA) is a newly discovered non-coding RNA. A large number of studies have reported that dysregulated circRNA mainly plays the role of miRNA sponges to regulate multiple phenotypes of cancer cells, including proliferation, invasion, migration, cycle arrest, and chemotherapy resistance. This molecule may also become a promising marker and target for cancer diagnosis and treatment. Compared with adult cancers, the study of circRNA in WT is still in its infancy. Based on the existing literature, this paper systematically reviewed the latest progress in the expression pattern, biological function, and clinical value of circRNA in WT, and discussed the limitations of current research and future directions."

基金机构：Natural Science Foundation of Chongqing [CSTC2021jcyj-msxmX0345]; General Project of Clinical Medicine Research of Children's Hospital of Chongqing Medical University [NCRC-2019-GP-08]; Chongqing Science and Health Joint Medical Research Project [2022GDRC009]

基金资助正文："This work was supported by grants from the Natural Science Foundation of Chongqing (CSTC2021jcyj-msxmX0345), General Project of Clinical Medicine Research of Children's Hospital of Chongqing Medical University (NCRC-2019-GP-08), and Chongqing Science and Health Joint Medical Research Project (2022GDRC009)."