Evaluation and Application of Silk Fibroin Based Biomaterials to Promote Cartilage Regeneration in Osteoarthritis Therapy

作者全名："Su, Xudong; Wei, Li; Xu, Zhenghao; Qin, Leilei; Yang, Jianye; Zou, Yinshuang; Zhao, Chen; Chen, Li; Hu, Ning"

作者地址："[Su, Xudong; Wei, Li; Xu, Zhenghao; Qin, Leilei; Yang, Jianye; Zou, Yinshuang; Zhao, Chen; Chen, Li; Hu, Ning] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing 400016, Peoples R China; [Su, Xudong; Wei, Li; Xu, Zhenghao; Qin, Leilei; Yang, Jianye; Zou, Yinshuang; Zhao, Chen; Chen, Li; Hu, Ning] Chongqing Med Univ, Lab Orthoped, Chongqing 400016, Peoples R China"

通信作者："Chen, L; Hu, N (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing 400016, Peoples R China.; Chen, L; Hu, N (通讯作者)，Chongqing Med Univ, Lab Orthoped, Chongqing 400016, Peoples R China."

来源：BIOMEDICINES

ESI学科分类：　

WOS号：WOS:001056052200001

JCR分区：Q1

影响因子：3.9

年份：2023

卷号：11

期号：8

开始页：　

结束页：　

文献类型：Review

关键词：silk fibroin; osteoarthritis; bone/cartilage repair; treatment

摘要："Osteoarthritis (OA) is a common joint disease characterized by cartilage damage and degeneration. Traditional treatments such as NSAIDs and joint replacement surgery only relieve pain and do not achieve complete cartilage regeneration. Silk fibroin (SF) biomaterials are novel materials that have been widely studied and applied to cartilage regeneration. By mimicking the fibrous structure and biological activity of collagen, SF biomaterials can promote the proliferation and differentiation of chondrocytes and contribute to the formation of new cartilage tissue. In addition, SF biomaterials have good biocompatibility and biodegradability and can be gradually absorbed and metabolized by the human body. Studies in recent years have shown that SF biomaterials have great potential in treating OA and show good clinical efficacy. Therefore, SF biomaterials are expected to be an effective treatment option for promoting cartilage regeneration and repair in patients with OA. This article provides an overview of the biological characteristics of SF, its role in bone and cartilage injuries, and its prospects in clinical applications to provide new perspectives and references for the field of bone and cartilage repair."

基金机构：General Project of National Natural Science Foundation of China [82072443]; Excellent Project of Chongqing Overseas Returnee Entrepreneurship and Innovation Support Program [CX2022032]; General Project of Chongqing Technology Innovation and Application Development Special Project [Cstc2020jscx-msxmx0094]; key project of Chongqing Science and Health Joint Medical Research Project [2019ZDXM014]

基金资助正文："General Project of National Natural Science Foundation of China (Project number: 82072443), Excellent Project of Chongqing Overseas Returnee Entrepreneurship and Innovation Support Program (Project number: CX2022032), General Project of Chongqing Technology Innovation and Application Development Special Project (Project number: Cstc2020jscx-msxmx0094), the key project of Chongqing Science and Health Joint Medical Research Project (Project number: 2019ZDXM014)."