Prevalence and risk factors of anxiety and depression in adult patients with epilepsy: a multicenter survey-based study

作者全名："Shi, Wenyan; Sun, Hanlin; Peng, Wei; Chen, Ziyi; Wang, Qun; Lin, Weihong; Ding, Meiping; Sun, Hongbin; Wang, Xiangqing; Wang, Tiancheng; Wang, Xuefeng; Liu, Yonghong; Chen, Yangmei; Zhu, Guoxing; Zhou, Dong; Li, Jinmei"

作者地址："[Zhou, Dong; Li, Jinmei] Sichuan Univ, West China Hosp, Dept Neurol, 37 Guoxue Lane, Chengdu 610041, Sichuan, Peoples R China; [Shi, Wenyan; Sun, Hanlin; Peng, Wei] Sichuan Univ, West China Hosp, Dept Neurol, Chengdu, Peoples R China; [Chen, Ziyi] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Neurol, Guangzhou, Peoples R China; [Wang, Qun] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China; [Lin, Weihong] First Hosp Jilin Univ, Dept Neurol, Changchun, Peoples R China; [Ding, Meiping] Zhejiang Univ, Affiliated Hosp 2, Dept Neurol, Hangzhou, Peoples R China; [Sun, Hongbin] Sichuan Prov Peoples Hosp, Dept Neurol, Chengdu, Peoples R China; [Wang, Xiangqing] Chinese Peoples Liberat Army Gen Hosp, Dept Neurol, Beijing, Peoples R China; [Wang, Tiancheng] Lanzhou Univ Second Hosp, Dept Neurol, Lanzhou, Peoples R China; [Wang, Xuefeng] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [Liu, Yonghong] Air Force Med Univ, Xijing Hosp, Dept Neurol, Xian, Peoples R China; [Chen, Yangmei] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, Chongqing, Peoples R China; [Zhu, Guoxing] Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai, Peoples R China"

通信作者："Zhou, D; Li, JM (通讯作者)，Sichuan Univ, West China Hosp, Dept Neurol, 37 Guoxue Lane, Chengdu 610041, Sichuan, Peoples R China."

来源：THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001057322200001

JCR分区：Q1

影响因子：4.7

年份：2023

卷号：16

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：anxiety; current status of treatment; depression; epilepsy; risk factors

摘要："Background:Depression and anxiety are the most common psychiatric comorbidities in patients with epilepsy (PWE). However, they are often unrecognized and consequently untreated.Objective:The study was conducted to evaluate the prevalence and risk factors of anxiety and depression among Chinese adult PWE.Design:Cross-sectional study.Methods:Adult PWE were recruited from 13 tertiary epilepsy centers from February to September 2022. Generalized Anxiety Disorder-7 and Neurological Disorders Depression Inventory for Epilepsy were applied to evaluate anxiety and depression, respectively. Both univariate and multivariate logistic regression analyses models were performed to explore the risk factors of anxiety and depression.Results:A total of 1326 PWE were enrolled in this study. The prevalence of anxiety and depression was 31.45% and 27.30%, respectively. Being female [odds ratio (OR) = 1.467, 95% CI: 1.134-1.899; p = 0.004], focal and focal to bilateral tonic-clonic seizures (TCSZ) (OR = 1.409, 95% CI: 1.021-1.939; p = 0.036), and seizure occurrence in the last 3 months (OR = 1.445, 95% CI: 1.026-2.044; p = 0.036) were the risk factors for anxiety. Focal and focal to bilateral TCSZ (OR = 1.531, 95% CI: 1.094-2.138; p = 0.013) and seizure occurrence in the last 3 months (OR = 1.644, 95% CI: 1.130-2.411; p = 0.010) were the risk factors for depression. In addition, for every 1-year increment of age, the odds of developing depression were decreased by 3.8% (p = 4.12e-5). Nevertheless, up to 70% of PWE did not receive any treatment for comorbidity.Conclusion:There were approximately 30% of PWE screened positive for anxiety or depression. Both focal and focal to bilateral TCSZ and seizure occurrence in the last 3 months were estimated as risk factors for anxiety and depression. However, the current status of treatment was not optimal."

基金机构："We are grateful to all the participants for their valuable information, cooperation, and participation."

基金资助正文："We are grateful to all the participants for their valuable information, cooperation, and participation."