"Platelet activation: a promoter for psoriasis and its comorbidity, cardiovascular disease"

作者全名："Jiang, Ziqi; Jiang, Xiaoran; Chen, Aijun; He, Wenyan"

作者地址："[Jiang, Ziqi; Chen, Aijun; He, Wenyan] Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China; [Jiang, Xiaoran] Chongqing Med Univ, Clin Coll 1, Chongqing, Peoples R China"

通信作者："Chen, AJ; He, WY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001057348300001

JCR分区：Q1

影响因子：5.7

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：platelet; psoriasis; cardiovascular disease; leukocyte; endothelial cell; cytokines

摘要："Psoriasis is a chronic inflammatory skin disease with a prevalence of 0.14% to 1.99%. The underlying pathology is mainly driven by the abnormal immune responses including activation of Th1, Th17, Th22 cells and secretion of cytokines. Patients with psoriasis are more likely to develop cardiovascular disease (CVD) which has been well recognized as a comorbidity of psoriasis. As mediators of hemostasis and thromboinflammation, platelets play an important part in CVD. However, less is known about their pathophysiological contribution to psoriasis and psoriasis-associated CVD. A comprehensive understanding of the role of platelet activation in psoriasis might pave the path for more accurate prediction of cardiovascular (CV) risk and provide new strategies for psoriasis management, which alleviates the increased CV burden associated with psoriasis. Here we review the available evidence about the biomarkers and mechanisms of platelet activation in psoriasis and the role of platelet activation in intriguing the common comorbidity, CVD. We further discussed the implications and efficacy of antiplatelet therapies in the treatment of psoriasis and prevention of psoriasis-associated CVD."

基金机构："This work was supported by the financial support from the National Natural Science Foundation of China (Grant No. 31971054, Grant No. 82273533 and Grant No. 81874238), the Natural Science Foundation of Chongqing (Grant No. CSTB2022NSCQ-MSX1063) and the res [82273533, 81874238, CSTB2022NSCQ-MSX1063]; National Natural Science Foundation of China; Natural Science Foundation of Chongqing; research foundation of the first affiliated hospital of Chongqing Medical University; [31971054]"

基金资助正文："The authors gratefully thank Figdraw for providing basic material for the artwork.r This work was supported by the financial support from the National Natural Science Foundation of China (Grant No. 31971054, Grant No. 82273533 and Grant No. 81874238), the Natural Science Foundation of Chongqing (Grant No. CSTB2022NSCQ-MSX1063) and the research foundation of the first affiliated hospital of Chongqing Medical University."