Catechol-Modified and MnO₂-Nanozyme-Reinforced Hydrogel with Improved Antioxidant and Antibacterial Capacity for Periodontitis Treatment

作者全名："Hu, Shanshan; Wang, Liping; Li, Jiao; Li, Dize; Zeng, Huan; Chen, Tao; Li, Lingjie; Xiang, Xuerong"

作者地址："[Hu, Shanshan; Wang, Liping; Li, Jiao; Li, Dize; Zeng, Huan; Chen, Tao; Li, Lingjie; Xiang, Xuerong] Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China"

通信作者："Li, LJ; Xiang, XR (通讯作者)，Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China."

来源：ACS BIOMATERIALS SCIENCE & ENGINEERING

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001058035900001

JCR分区：Q2

影响因子：5.4

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：hydrogel; mussel; MnO2 nanoparticle; antioxidant; antibacterial; periodontitis

摘要："Periodontitis is an inflammatory disease characterized by tooth loss and alveolar bone resorption. Bacteria are the original cause of periodontitis, and excess reactive oxygen species (ROS) encourage and intensify inflammation. In this study, a mussel-inspired and MnO2 NPs-reinforced adhesive hydrogel capable of alleviating periodontitis with improved antibacterial and antioxidant abilities was developed. The hydrogel was created by combining polyvinyl alcohol (PVA), 3,4-dihydroxy-Dphenylalanine (DOPA), and MnO2 nanoparticles (NPs) (named PDMO hydrogel). The hydrogel was demonstrated to be able to scavenge various free radicals (including total ROS-O-2(center dot-) and OH center dot) and relieve the hypoxia in an inflammatory microenvironment by scavenging excess ROS and generating O-2 due to its superoxide dismutase (SOD)/catalase (CAT)-like activity. Besides, under 808 nm near-infrared (NIR) light, the photothermal performance of the PDMO hydrogel displayed favorable antibacterial and antibiofilm effects toward Escherichia coli, Staphylococcus aureus, and Porphyromonas gingivalis (up to nearly 100% antibacterial rate). Furthermore, the PDMO hydrogel exhibited favorable therapeutic efficacy in alleviating gingivitis in Sprague-Dawley rats, even comparable to or better than the commercial PERIO. In addition, in the periodontitis models, the PDMO2 group showed the height of the residual alveolar bone and the smallest shadow area of low density among other groups, indicating the positive role of the PDMO2 hydrogel in bone regeneration. Finally, the biosafety of the PDMO hydrogel was comprehensively investigated, and the hydrogel was demonstrated to have good biocompatibility. Therefore, the developed PDMO hydrogel provided an effective solution to resolve biofilm recolonization and oxidative stress in periodontitis and could be a superior candidate for local drug delivery system in the clinical management of periodontitis with great potential for future clinical translation."

基金机构：National Natural Science Foundation of China [2020M683265]; Science and Technology Research Program of Chongqing Municipal Education Commission [2010010005393991]; China Postdoctoral Science Foundation [csts2020jcyj-bshX0022]; Chongqing Post-doctoral Science Special Foundation; Natural Science Foundation of Chongqing; [82101066]

基金资助正文："This work was supported by grants from the NationalNatural Science Foundation of China (82101066), the Science and TechnologyResearch Program of Chongqing Municipal Education Commission (KJQN-202200416),the China Postdoctoral Science Foundation (2020M683265), the ChongqingPost-doctoral Science Special Foundation (2010010005393991), and theNatural Science Foundation of Chongqing (csts2020jcyj-bshX0022)."