Associations between systemic immune-inflammation index and abdominal aortic calcification: Results of a nationwide survey

作者全名："Xie, Ruijie; Liu, Xiaozhu; Wu, Haiyang; Liu, Mingjiang; Zhang, Ya"

作者地址："[Xie, Ruijie; Liu, Mingjiang] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Hand & Microsurg, Hengyang 421002, Peoples R China; [Xie, Ruijie] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 581, D-69120 Heidelberg, Germany; [Xie, Ruijie] Heidelberg Univ, D-69117 Heidelberg, Germany; [Liu, Xiaozhu] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing, Peoples R China; [Wu, Haiyang] Tianjin Med Univ, Dept Grad Sch, 22 Qixiangtai Rd, Tianjin 300070, Peoples R China; [Wu, Haiyang] Duke Univ, Duke Univ Sch Med, Duke Mol Physiol Inst, Durham, NC USA; [Zhang, Ya] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Gland Surg, Hengyang 421002, Peoples R China"

通信作者："Liu, MJ (通讯作者)，Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Hand & Microsurg, Hengyang 421002, Peoples R China.; Wu, HY (通讯作者)，Tianjin Med Univ, Dept Grad Sch, 22 Qixiangtai Rd, Tianjin 300070, Peoples R China.; Zhang, Y (通讯作者)，Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Gland Surg, Hengyang 421002, Peoples R China."

来源：NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001058119500001

JCR分区：Q2

影响因子：3.3

年份：2023

卷号：33

期号：7

开始页：1437

结束页：1443

文献类型：Article

关键词：Systemic immune-inflammation index; Abdominal aortic calcification; Cardiovascular disease; NHANES

摘要："Background and aim: The Systemic Immune-Inflammation Index (SII) is a novel index of inflammation assessment that appears to be superior to the common single blood index in the assessment of cardiovascular disease. The purpose of this study was to investigate the association between SII and abdominal aortic calcification (AAC) in adults. Methods and results: Multivariate logistic regression, sensitivity analysis, and smoothing curve fitting were used to investigate the relationship between SII and AAC based on data from the National Health and Nutrition Examination Survey (NHANES) 2013e2014. Subgroup analysis and interaction tests were used to investigate whether this association was stable across populations. There was a positive association between SII and ACC in 3036 participants >40 years of age. In the fully adjusted model, each 100-unit increase in SII was associated with a 4% increase in the risk of developing severe AAC [1.04 (1.02, 1.07)]. Participants in the highest quartile of SII had a 47% higher risk of developing severe AAC than those in the lowest quartile [1.47 (1.10, 1.99)]. This positive association was more pronounced in older adults >60 years of age. Conclusions: SII is positively associated with AAC in US adults. Our findings imply that SII has the potential to improve AAC prevention in the general population. (c) 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved."

基金机构：clinical research center of hand and foot Wound repair and Functional Reconstruction in Hunan province [2021SK4030]; Major Special Project of Hunan Provincial Health and Family Planning Commission [20201906]

基金资助正文：This study Funded by The clinical research center of hand and foot Wound repair and Functional Reconstruction in Hunan province (Item number:2021SK4030) and The Major Special Project of Hunan Provincial Health and Family Planning Commission (Item number:20201906).