Titanium implants with antiaging effect to repair senile osteoporosis fracture

作者全名："Li, Kai; Tao, Bailong; Tian, Hongchuan; Wu, Junjie; Huang, Ke; Yan, Caiping; Chen, Sinan; Guo, Ai; Jiang, Dianming"

作者地址："[Li, Kai; Huang, Ke; Yan, Caiping; Guo, Ai; Jiang, Dianming] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 3, Chongqing 401120, Peoples R China; [Tao, Bailong] Chongqing Med Univ, Lab Res Ctr, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Tian, Hongchuan; Chen, Sinan] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing 400010, Peoples R China; [Wu, Junjie] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Guo, A; Jiang, DM (通讯作者)，Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 3, Chongqing 401120, Peoples R China."

来源：MATERIALS & DESIGN

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001058274400001

JCR分区：Q1

影响因子：7.6

年份：2023

卷号：232

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Titanium nanotube; Senile osteoporosis; Osteointegration; Irisin; Bone healing

摘要："Accelerated population ageing has brought a great burden to the development of society. Repairing senile osteoporosis fractures is a great challenge, but a desirable way to address this issue is by developing mul-tifunctional titanium(Ti) implants with antiaging and pro-osteogenic effects. Herein, to endow TI sub-strate with an antiaging effect for enhanced bone formation, an exercise-induced myokine(irisin) was loaded on titanium dioxide nanotubes(TNTs) and then a multilayered structure composed of chitosan (Chi) and gelatin(Gel) was constructed on the substrates via a layer-by-layer-assembly technique(TNT-IR-LBL). The surface topography of TNT-IR-LBL was characterized by scanning electron microscopy (SEM), atomic force microscopy(AFM), X-ray photoelectron spectroscopy(XPS) and water contact angle measurements, respectively. As an exercise-induced myokine, the irisin secreted from skeletal muscle exhibits strong activity for against the chronic diseases. The implants synthesized here displayed good biocompatibility towards osteoblasts. Moreover, irisin was sustainably released from TNT-IR-LBL for more than 3 weeks. In vitro studies indicated the TNT-IR-LBL substrates promoted osteoblast differenti-ation. In addition, compared to bare titanium, TNT-IR-LBL significantly promoted new bone formation around the implant interface in senile osteoporosis rats 4 weeks after implantation. Overall, this study provides a promising candidate to develop Ti-based orthopaedic implants to repair senile osteoporosis fractures. & COPY; 2023 The Author(s). Published by Elsevier Ltd.This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)."

基金机构：Techni- cal Innovation and Application Development Project of the Science and Technology Bureau of Chongqing [CSTB2022NSCQ- BHX0005]; Postdoctoral Science Foundation of Chongq- ing Science and Technology Bureau; [cstc2020jscx- msxmX0219]

基金资助正文："<BOLD>Acknowledgements</BOLD> This work was financially supported by grants from the Techni- cal Innovation and Application Development Project of the Science and Technology Bureau of Chongqing (No. cstc2020jscx- msxmX0219) , and the Postdoctoral Science Foundation of Chongq- ing Science and Technology Bureau (No. CSTB2022NSCQ- BHX0005) ."