The safety and immunogenicity to inactivated COVID-19 vaccine in patients with hyperlipemia

作者全名："Yang, Lei; Liu, YaMing; Guo, Qiao; Jiang, DePeng"

作者地址："[Yang, Lei; Jiang, DePeng] Chongqing Med Univ, Affiliated Hosp 2, Dept Resp Med, Chongqing, Peoples R China; [Liu, YaMing] Chongqing Med Univ, Affiliated Hosp 2, Dept Emergency, Chongqing, Peoples R China; [Guo, Qiao] Chongqing Med Univ, Affiliated Hosp 2, Dept Gen Practice, Chongqing, Peoples R China"

通信作者："Jiang, DP (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Resp Med, Chongqing, Peoples R China."

来源：OPEN MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001059188000001

JCR分区：Q2

影响因子：1.7

年份：2023

卷号：18

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：COVID-19 vaccine; safety; effectiveness; hyperlipidemia

摘要："It is of urgent need to understand the safety and effectiveness of novel coronavirus (COVID-19)-inactivated vaccine in patients with hyperlipidemia (HLD). However, data on the safety and immune response of SARS-CoV-2-inactivated vaccine in HLD patients are limited. In this prospective study, 105 patients with HLD and 74 healthy controls (HCs) were selected. Within 16-168 days after inoculation-inactivated vaccine, the anti-receptor-binding domain (RBD) IgG and SARS-CoV-2 neutralizing antibodies (NAbs) were evaluated, respectively. Flow cytometry was performed to evaluate RBD-specific B cells and memory B cells. There was no significant difference between HLD patients and HCs in adverse events (AEs) within 7 days after vaccination, and no serious AEs occurred. The seropositivity rates and titers of two Abs (anti-RBD IgG and CoV-2 NAbs) were lower in HLD patients than in HCs (all, p < 0.05). HLD showed significantly lower frequencies of RBD-specific B cells than HCs (p = 0.040). However, in high cholesterol, high triglyceride, mixed (MiX), and lipid control (HC) subgroups, there was no significant difference in the seropositivity rates and titers of the both Abs. Through mixed factor analysis shows that days between the second dose and sample collection/antibody measurement were associated with the lower anti-RBD IgG antibody levels. In conclusion, inactivated COVID-19 vaccine is safe and well tolerated for HLD patients, but the humoral immune may be limited."

基金机构："National Science and Technology Major Project of China [2017ZX10202203-007, 2017ZX10202203-008, 2018ZX10302206-003]; National Natural Science Foundation of China [81772198]; Natural Science Foundation of Chongqing, China [cstc2020jcyj-msxmX0389]; Kuanren Talents Program of the second affiliated Hospital of Chongqing Medical University"

基金资助正文："& nbsp;This work is supported by the National Science and Technology Major Project of China (2017ZX10202203-007, 2017ZX10202203-008, 2018ZX10302206-003) and a pilot project of clinical cooperation between traditional Chinese and western medicine for significant and complicated diseases of National Administration of Traditional Chinese Medicine: hepatic fibrosis. We also acknowledge the support of the National Natural Science Foundation of China (81772198), the Natural Science Foundation of Chongqing, China (cstc2020jcyj-msxmX0389), and the Kuanren Talents Program of the second affiliated Hospital of Chongqing Medical University."