Potential roles for lncRNA Mirg/Foxp1 in an ARHL model created using C57BL/6J mice

作者全名："Luo, Xiaoqin; Hu, Yaqin; Zhou, Xiaoqing; Zhang, Chanyuan; Feng, Menglong; Yang, Ting; Yuan, Wei"

作者地址："[Luo, Xiaoqin; Hu, Yaqin; Zhou, Xiaoqing; Zhang, Chanyuan; Feng, Menglong; Yang, Ting; Yuan, Wei] Chongqing Med Univ, Dept Otolaryngol, Chongqing 400042, Peoples R China; [Luo, Xiaoqin; Hu, Yaqin; Zhou, Xiaoqing; Zhang, Chanyuan; Feng, Menglong; Yang, Ting; Yuan, Wei] Univ Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China; [Luo, Xiaoqin; Hu, Yaqin; Zhou, Xiaoqing; Zhang, Chanyuan; Feng, Menglong; Yang, Ting; Yuan, Wei] Univ Chinese Acad Sci, Chongqing Sch, Dept Otolaryngol, Chongqing 400714, Peoples R China; [Luo, Xiaoqin; Hu, Yaqin; Zhou, Xiaoqing; Zhang, Chanyuan; Feng, Menglong; Yang, Ting; Yuan, Wei] Chongqing Gen Hosp, Dept Otolaryngol, Chongqing 400014, Peoples R China"

通信作者："Yuan, W (通讯作者)，Chongqing Med Univ, Dept Otolaryngol, Chongqing 400042, Peoples R China.; Yuan, W (通讯作者)，Univ Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China.; Yuan, W (通讯作者)，Univ Chinese Acad Sci, Chongqing Sch, Dept Otolaryngol, Chongqing 400714, Peoples R China.; Yuan, W (通讯作者)，Chongqing Gen Hosp, Dept Otolaryngol, Chongqing 400014, Peoples R China."

来源：HEARING RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001059216800001

JCR分区：Q1

影响因子：2.5

年份：2023

卷号：438

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：LncRNA Mirg; Cochlear hair cell; Foxp1; Apoptosis; Age-related hearing loss

摘要："Age-related hearing loss (ARHL) is associated with hair cell apoptosis, but the underlying mechanism of hair cell apoptosis remains unclear. Here, we investigated the expression profiles of long noncoding RNAs (lncRNAs) and mRNAs in an ARHL model created with C57BL/6 J mice using RNA sequencing and found that the expression of several lncRNAs was significantly correlated with apoptosis-associated mRNAs in the cochlear tissues of old mice compared to young mice. We found that lncRNA Mirg was upregulated in the cochlear tissues of old mice compared to young mice and its overexpression promoted apoptosis in House Ear Institute-Organ of Corti 1 (HEI-OC1). H2O2-induced oxidative stress increased HEI-OC1 cell apoptosis by upregulating lncRNA Mirg. Further-more, the expression of lncRNA Mirg and Foxp1 showed the highest correlation coefficient in the cochlear tissues of old mice, and lncRNA Mirg promoted HEI-OC1 cell apoptosis by increasing Foxp1 expression. In conclusion, our findings suggest that lncRNA Mirg expression correlates with cell apoptosis-associated mRNAs in the ARHL model created using C57BL/6 J mice and that oxidative stress-induced lncRNA Mirg promotes HEI-OC1 cell apoptosis by increasing Foxp1 expression. These data suggest the potential therapeutic significance of targeting lncRNA Mirg/Foxp1 signaling in ARHL."

基金机构："National Natural Science Foundation of China [81470694, 81271080]; [81873702]"

基金资助正文："This work was supported by grants from the National Natural Science Foundation of China (81873702, 81470694, and 81271080) to Wei Yuan."