An in?vitro and in?vivo study on extracorporeal transducer optimization for high-intensity focused ultrasound to improve the safety and efficacy of breast tumor ablation

作者全名："Hong, Liu; Zhang, Wendy; Pan, Feibao; Xiaobo, Gong; Huang, Haoran; You, Yaqing; Deng, Lulu; Wang, Zhibiao; Zhang, Cai"

作者地址："[Hong, Liu; Xiaobo, Gong; Huang, Haoran; You, Yaqing; Deng, Lulu; Wang, Zhibiao; Zhang, Cai] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Hong, Liu; Xiaobo, Gong; Huang, Haoran; You, Yaqing; Deng, Lulu; Wang, Zhibiao; Zhang, Cai] Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing, Peoples R China; [Hong, Liu; Xiaobo, Gong; Huang, Haoran; You, Yaqing; Deng, Lulu; Zhang, Cai] Natl Engn Res Ctr Ultrasound Med, Chongqing, Peoples R China; [Zhang, Wendy] Staten Isl Univ Hosp, Dept Radiol, Staten Isl, NY USA; [Pan, Feibao] Suining Cent Hosp, Dept Cerebrovasc Dis, Suining, Peoples R China; [Huang, Haoran; Wang, Zhibiao; Zhang, Cai] Chongqing Haifu Hosp, Chongqing, Peoples R China; [Wang, Zhibiao; Zhang, Cai] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Xueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Wang, ZB; Zhang, C (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Xueyuan Rd, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF HYPERTHERMIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001060064300001

JCR分区：Q2

影响因子：3

年份：2023

卷号：40

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：High-intensity focused ultrasound; transducer; biological focal region; breast tumor

摘要："Objective: To observe the characteristics of a new extracorporeal high intensity focused ultrasound transducer, titled Haifu system JCQ-B, and to compare its safety and efficacy for breast ablation with the standard Haifu system JC transducer.Materials and methods: Ox liver with pig skin and pork ribs were prepared in a semi-sphere shape, served as in vitro acoustic model. The udders of female goats were used as in vivo acoustic model. Both in vitro and in vivo models were ablated by either JCQ-B or JC transducer. The morphology of biological focal region (BFR), the coagulative necrosis volume, and the temperature increase were observed and compared.Results: The BFR morphology of JCQ-B transducer was circular both in vitro and in vivo, with a length-width ratio close to one. Under the same sonication parameters (sonication power, time and depth in tissue), coagulation necrosis volume caused by JCQ-B transducer was larger than that caused by JC transducer both in vitro and in vivo. The increase in temperature in the near and far acoustic pathways with JCQ-B transducer was significantly lower than that of JC transducer in vitro. After receiving high sonication energy during in vivo experimentation, there were no complications observed after the ablation of JCQ-B transducer, while small skin damage was observed after the ablation of JC transducer.Conclusions: The JCQ-B transducer improved the safety and efficacy of treatment by optimizing BFR morphology and ablation efficiency, which could be applied in the treatment of breast tumor."

基金机构：Chongqing Graduate Research Innovation Project [CYS22375]

基金资助正文：This work was partially supported by the [Chongqing Graduate Research Innovation Project] under Grant [CYS22375]