U-fiber diffusion kurtosis and susceptibility characteristics in relapsing-remitting multiple sclerosis may be related to cognitive deficits and neurodegeneration

作者全名："Luo, Dan; Peng, Yuling; Zhu, Qiyuan; Zheng, Qiao; Luo, Qi; Han, Yongliang; Chen, Xiaoya; Li, Yongmei"

作者地址："[Luo, Dan; Peng, Yuling; Zhu, Qiyuan; Zheng, Qiao; Luo, Qi; Han, Yongliang; Chen, Xiaoya; Li, Yongmei] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Chen, XY; Li, YM (通讯作者)，Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：EUROPEAN RADIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001060204700001

JCR分区：Q1

影响因子：4.7

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Multiple sclerosis; Diffusion magnetic resonance imaging; Cognitive dysfunction; Atrophy

摘要："Objectives To evaluate the diffusion kurtosis and susceptibility change in the U-fiber region of patients with relapsing-remitting multiple sclerosis (pwRRMS) and their correlations with cognitive status and degeneration.Materials and methods Mean kurtosis (MK), axial kurtosis (AK), radial kurtosis (RK), kurtosis fractional anisotropy (KFA), and the mean relative quantitative susceptibility mapping (mrQSM) values in the U-fiber region were compared between 49 pwRRMS and 48 healthy controls (HCs). The U-fiber were divided into upper and deeper groups based on the location. The whole brain volume, gray and white matter volume, and cortical thickness were obtained. The correlations between the mrQSM values, DKI-derived metrics in the U-fiber region and clinical scale scores, brain morphologic parameters were further investigated.Results The decreased MK, AK, RK, KFA, and increased mrQSM values in U-fiber lesions (p < 0.001, FDR corrected), decreased RK, KFA, and increased mrQSM values in U-fiber non-lesions (p = 0.034, p < 0.001, p < 0.001, FDR corrected) were found in pwRRMS. There were differences in DKI-derived metrics and susceptibility values between the upper U-fiber region and the deeper one for U-fiber non-lesion areas of pwRRMS and HCs (p < 0.05), but not for U-fiber lesions in DKI-derived metrics. The DKI-derived metrics and susceptibility values were widely related with cognitive tests and brain atrophy.Conclusion RRMS patients show abnormal diffusion kurtosis and susceptibility characteristics in the U-fiber region, and these underlying tissue abnormalities are correlated with cognitive deficits and degeneration.Clinical relevance statement The macroscopic and microscopic tissue damages of U-fiber help to identify cognitive impairment and brain atrophy in multiple sclerosis and provide underlying pathophysiological mechanism."

基金机构：Key Project of Technological Innovation and Application Development of Chongqing Science and Technology Bureau (CSTC) [jscx-gksb-N0008]

基金资助正文：This study received grants from the Key Project of Technological Innovation and Application Development of Chongqing Science and Technology Bureau (CSTC2021 jscx-gksb-N0008).