Versatile hydrogel facilitating angiogenesis and cell recruitments for enhanced calvarial bone regeneration

作者全名："Tan, Xiujun; Wang, Rui; Li, Xiaohong; Wang, Chenglin; Wang, Zhenming; Ye, Ling"

作者地址："[Tan, Xiujun; Wang, Rui; Li, Xiaohong; Wang, Chenglin; Wang, Zhenming; Ye, Ling] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China; [Tan, Xiujun] Chongqing Med Univ, Stomatol Hosp, Chongqing 401147, Peoples R China; [Wang, Zhenming] Sichuan Univ, West China Sch Stomatol, 14,3th Sect,South Renmin Rd, Chengdu 610041, Peoples R China"

通信作者："Wang, ZM (通讯作者)，Sichuan Univ, West China Sch Stomatol, 14,3th Sect,South Renmin Rd, Chengdu 610041, Peoples R China."

来源：MATERIALS & DESIGN

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001060721200001

JCR分区：Q1

影响因子：7.6

年份：2023

卷号：232

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Versatile hydrogels; Cranioplasty; Cell recruitment; Angiogenesis; Bone regeneration

摘要："ABSTR A C T The repair of large-size cranial bone defects caused by traumatic brain injury (TBI) remains a substantial clinical challenge. On one hand, traditional bone implants with intrinsic brittle and poor recovery fea-tures hinder their immediate implantation for cranioplasty applications. On the other hand, using exoge-nous growth factors to enhance the osteo-bioactivity of bone implants often leads to efficacy, safety, and cost concerns. Thus far, the authors develop a growth factor-free pliable hydrogel with multiple functions for mediating endogenous growth factor production and stem cell functions in cranioplasty. The pliable hydrogels are based on GelMA networks, in which the mechanical properties and protein affinity were strengthened by the crosslinked poly (ethylene glycol) disuccinimidyl succinate (PEG-(SS)2), while the antioxidant capability and osteoinductivity were remarkedly enhanced through the decoration of magnesium-seamed C-propylpyrogallol[4]arene cages (PgC3Mg). In vitro and in vivo results confirmed that the versatile hydrogel with excellent biocompatibility and biodegradability can improve osteogenic differentiation and cranial bone regeneration by facilitating growth factor production, endogenous cell recruitment and angiogenesis. These findings indicate that the versatile hydrogels represent a potential avenue for developing growth factor-free pliable scaffolds in cranioplasty after TBI. & COPY; 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/)."

基金机构："National Science Fund for Distinguished Young Scholars of China [81825005]; Natural Science Foundation of China [81702162]; Sichuan International Science and Technology Innovation Cooperation Project of Hong Kong, Macao and Taiwan [2021YFH0185]; Sichuan Provincial Science and Technology Department Project [23NSFSC0566]; West China School/Hospital of Stomatology Sichuan University [QDJF2021-1]"

基金资助正文："This work was supported by the National Science Fund for Distinguished Young Scholars of China (Grant No. 81825005), Natural Science Foundation of China (Grant No. 81702162), Sichuan International Science and Technology Innovation Cooperation Project of Hong Kong, Macao and Taiwan (Grant No. 2021YFH0185), Sichuan Provincial Science and Technology Department Project (Grant No: 23NSFSC0566), and Research Funding from West China School/Hospital of Stomatology Sichuan University (Grant No. QDJF2021-1)."