Prognostic characteristics of T-cell mediated cell killing-related genes in lung adenocarcinoma

作者全名："Bi, Lei; Ai, Cheng; Zhang, Hong; Chen, Zhengyu; Deng, Yiping; Xiong, Jing; Lv, Zhongzhu"

作者地址："[Bi, Lei; Ai, Cheng; Zhang, Hong; Chen, Zhengyu; Deng, Yiping; Xiong, Jing; Lv, Zhongzhu] Chongqing Med Univ, Bishan Hosp, Dept Cardiothorac Surg, Chongqing, Peoples R China; [Lv, Zhongzhu] Chongqing Med Univ, Bishan Hosp, Dept Cardiothorac Surg, 9 Shuangxing Ave, Chongqing 402760, Peoples R China"

通信作者："Lv, ZZ (通讯作者)，Chongqing Med Univ, Bishan Hosp, Dept Cardiothorac Surg, 9 Shuangxing Ave, Chongqing 402760, Peoples R China."

来源：AUTOIMMUNITY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001061345400001

JCR分区：Q3

影响因子：3.3

年份：2023

卷号：56

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Lung adenocarcinoma; T cells; tumor killing; prognostic model; immunotherapy

摘要："Constituted by various heterogeneous cells, the tumor microenvironment (TME) is capable of promoting tumor proliferation, invasion, and metastasis through extensive crosstalk. The pivotal factor influencing the survival time of patients and their response to immunotherapy lies in the intratumoral immune environment. We obtained 112 differential genes related to T cell-mediated tumor killing in LUAD by employing bioinformatics analysis on the basis of the TCGA and TISIDB databases. Then the 6-gene prognostic risk score model (CA9, OIP5, TIMP1, SEC11C, FURIN, and TLR10) was constructed by conducting univariate LASSO as well as multivariate Cox regression analyses. The median risk score was taken as the threshold to classify the samples into two groups. Survival analysis revealed that the low-risk group exhibited a more favorable prognosis. Subsequently, the Cox regression analysis combined with clinical information (age, gender, and pathological stage) and the risk score of LUAD patients demonstrated the potential of this model as an independent prognostic factor. The nomogram established based on clinical information and a risk score in combination with the calibration curve indicated that this model had good predictive ability. Notable enrichment of the differential genes from the high- and low-risk groups was discovered in immune-associated processes or pathways, as shown by the GO and KEGG enrichment analyses. The combined use of single-sample gene enrichment analysis (ssGSEA) and immunophenoscore (IPS) demonstrated heightened immune infiltration and IPS scores in the low-risk group, indicating that immunotherapy was likely to show good efficacy in patients from this group. To sum up, the prognostic model of LUAD constructed based on T-cell-mediated cell killing-related genes was not only capable of screening the prognosis of LUAD patients but was also used for screening those LUAD patients with high sensitivity to immunotherapy. Our study offered novel insights into the clinical treatment and prognostic prediction of LUAD patients."

基金机构：Natural Science Foundation of Chongqing CSTC [cstc2021jcyj-msxm4159]

基金资助正文：This work was supported by the Natural Science Foundation of Chongqing CSTC (cstc2021jcyj-msxm4159).