Understanding the molecular pathogenesis of primary central nervous system lymphoma by experimental animal models

作者全名："Wu, Di; Liu, Dahai; Tateishi, Kensuke; Qi, Fei; Yang, Fang; Ke, Chao; You, Hua"

作者地址："[Wu, Di; Liu, Dahai; Yang, Fang] Foshan Univ, Sch Med, Dept Basic Med, Foshan, Guangdong, Peoples R China; [Tateishi, Kensuke] Yokohama City Univ, Grad Sch Med, Dept Neurosurg, Yokohama, Japan; [Qi, Fei] Peking Univ, Shenzhen Hosp, Dept Pulm & Crit Care Med, Shenzhen, Guangdong, Peoples R China; [Ke, Chao] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Dept Neurosurg Neurooncol, State Key Lab Oncol South China,Canc Ctr, Guangzhou 510060, Peoples R China; [You, Hua] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Pediat Hematol & Oncol, China Int Sci & Technol Cooperat Base Child Dev &, 136 Zhongshan Second Rd, Chongqing 401122, Peoples R China"

通信作者："You, H (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Pediat Hematol & Oncol, China Int Sci & Technol Cooperat Base Child Dev &, 136 Zhongshan Second Rd, Chongqing 401122, Peoples R China."

来源：JOURNAL OF CELLULAR PHYSIOLOGY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001061790900001

JCR分区：Q1

影响因子：4.5

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：animal models; migration; primary central nervous system lymphoma; tropism

摘要："Primary central nervous system lymphoma (PCNSL) is a rare and invasive diffuse large B cell lymphoma confined in central nervous system (CNS). The effort to press forward the translational progress has been frustrated by the insufficient understanding of immunophenotype of CNS and tumor genetic alterations of PCNSL, and the lack of validated diagnostic biomarkers. Researchers now have a variety of PCNSL animal models at their disposal that resemble the morphology and immunophenotype of PCNSL, however, a careful and detailed re-examination of these animal models is needed to clarify the differences in genetic alterations, migration capability, and immune status. In this review, we present the knowledge about the phenotypic and genotypic features of PCNSL tumor cells, and compile the preclinical animal models of PCNSL with regard to various injection sites, cell origins, recipient animals, and immune status, and elaborate on the tropism and migration of tumor cells and novel therapeutic strategies for PCNSL. We envisage that the selection of suitable animal models will serve as a well-defined preclinical system to understand the molecular pathogenesis of PCNSL, thereby galvanizing the development of novel and potent therapeutic approaches."

基金机构："National Natural Science Foundation of China [81911530169, 82270413, 81870307]; Natural Science Foundation of Guangdong Province of China [2022A1515011368, 2023A1515011581]; Key Projects of Department of Education of Guangdong Province of China [2022ZDZX2057, 2022ZXKC474]; Guangdong Basic and Applied Basic Research Foundation [2021A1515010083, 2022A1515111169]; CQMU Program for Youth Innovation in Future Medicine [W0202]; Talent Program of Chongqing Health Commission"

基金资助正文："National Natural Science Foundation of China, Grant/Award Numbers: 81911530169, 82270413, 81870307; The Natural Science Foundation of Guangdong Province of China, Grant/Award Numbers: 2022A1515011368, 2023A1515011581; The Key Projects of Department of Education of Guangdong Province of China, Grant/Award Numbers: 2022ZDZX2057, 2022ZXKC474; Guangdong Basic and Applied Basic Research Foundation, Grant/Award Numbers: 2021A1515010083, 2022A1515111169; CQMU Program for Youth Innovation in Future Medicine, Grant/Award Number: W0202; Talent Program of Chongqing Health Commission"