MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH
作者全名："Cao, Yunchuan; Wang, Yingwen; Li, Xiaoguo; Yang, Xiaomin; Zeng, Bo; Guo, Zongduo"
作者地址："[Cao, Yunchuan; Wang, Yingwen; Li, Xiaoguo; Yang, Xiaomin; Zeng, Bo; Guo, Zongduo] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, 1 Youyi Rd, Chongqing 400016, Peoples R China"
通信作者："Guo, ZD (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, 1 Youyi Rd, Chongqing 400016, Peoples R China."
来源：BRAIN RESEARCH BULLETIN
ESI学科分类：NEUROSCIENCE & BEHAVIOR
WOS号：WOS:001063298500001
JCR分区：Q2
影响因子：3.5
年份：2023
卷号：202
期号：
开始页：
结束页：
文献类型：Article
关键词：Subarachnoid hemorrhage; White matter microstructure; Cognitive function; NLRP3 inflammasome; MCC950
摘要："Neuroinflammation and white matter microstructure damage are important causes of cognitive impairment after subarachnoid hemorrhage (SAH). Nod-like receptor protein 3 (NLRP3) plays an important role in neuroinflammation after SAH and may be a potential therapeutic target for treatment of white matter microstructure injury. In this study, we observed whether MCC950, a specific inhibitor of the NLRP3 inflammasome, exerted a therapeutic effect after SAH. The SAH model was induced by endovascular perforation in Sprague-Dawley rats. MCC950 was injected intraperitoneally 1 h after SAH at a dose of 10 mg/kg. The results showed that MCC950 significantly attenuated white matter microstructure damage in some brain regions, and behavioral experiments confirmed that MCC950 ameliorated cognitive function in rats after SAH, which may provide a new method for the treatment of cognitive dysfunction in SAH patients."
基金机构：National Natural Science Foundation of China [82071332]; Key Project of Chongqing Science and Health Joint Medical Research Project [2020GDRC024]
基金资助正文：This work was supported by grants from the National Natural Science Foundation of China (Grant number 82071332) and the Key Project of Chongqing Science and Health Joint Medical Research Project (2020GDRC024).
