Risk factors of deep vein thrombosis in children with osteomyelitis

作者全名："He, Yunjian; Liu, Shaoshan; Su, Yuxi"

作者地址："[He, Yunjian; Liu, Shaoshan; Su, Yuxi] Chongqing Med Univ, Orthoped Dept, Childrens Hosp, 136 Zhongshan 2 Rd, Chongqing 400014, Peoples R China; [He, Yunjian; Liu, Shaoshan; Su, Yuxi] Minist Educ, Key Lab Child Dev & Disorders, Chongqing Key Lab Pediat, Chongqing, Peoples R China; [He, Yunjian; Liu, Shaoshan; Su, Yuxi] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China; [He, Yunjian; Liu, Shaoshan; Su, Yuxi] Chongqing Med Univ, Jiangxi Hosp, Affiliated Childrens Hosp, China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China"

通信作者："Su, YX (通讯作者)，Chongqing Med Univ, Orthoped Dept, Childrens Hosp, 136 Zhongshan 2 Rd, Chongqing 400014, Peoples R China."

来源：ANNALS OF MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001063548200001

JCR分区：Q1

影响因子：4.9

年份：2023

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文献类型：Article; Early Access

关键词：Thrombotic; osteomyelitis; methicillin-resistant Staphylococcus aureus; children

摘要："ObjectiveTo investigate the risk factors for deep vein thrombosis (DVT) in children with osteomyelitis and provide diagnostic and treatment strategies for the prevention, early detection and treatment of DVT.Study designThe clinical data of nine children diagnosed with osteomyelitis and DVT between July 2012 and March 2021 were collected at our hospital, including age, sex, clinical manifestations, body temperature, coagulation function and other data, as well as the clinical data of 27 children diagnosed with osteomyelitis without DVT during the same period. Thirty-six children were divided into thrombus and thrombus-free groups. The clinical characteristics and risk factors for DVT in children with osteomyelitis were analysed.ResultsAmong the 36 children in this study, nine cases of thrombus formation mainly occurred in the femoral vein, popliteal vein and iliac vein, all near the infection site. The main clinical manifestations were lower extremity pain, swelling and pulmonary embolism in three cases. Among them, intensive care unit (ICU) admission, sepsis, higher D-dimer, higher body temperature during hospitalization, and pathogen culture showed that methicillin-resistant Staphylococcus aureus (MRSA) was associated with DVT. MRSA was the independent risk factor for DVT.ConclusionsAdmission to ICU, sepsis, higher D-dimer, higher body temperature during hospitalization, and MRSA are risk factors for thrombosis. MRSA is the independent risk factor for DVT. For patients with related risk factors, timely ultrasound examination of the infected site should be considered to achieve early detection and treatment."

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