Functional molecule-mediated assembled copper nanozymes for diabetic wound healing

作者全名："Huang, Wenyan; Xu, Ping; Fu, Xiaoxue; Yang, Jiaxin; Jing, Weihong; Cai, Yucen; Zhou, Yingjuan; Tao, Rui; Yang, Zhangyou"

作者地址："[Huang, Wenyan; Xu, Ping; Fu, Xiaoxue; Yang, Jiaxin; Jing, Weihong; Cai, Yucen; Zhou, Yingjuan; Yang, Zhangyou] Chongqing Med Univ, Coll Pharm, Chongqing Pharmacodynam Evaluat Engn Technol Res C, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China; [Tao, Rui] Chongqing Med Univ, Bishan Hosp, Dept Hepatobiliary Surg, Chongqing 402760, Peoples R China"

通信作者："Yang, ZY (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Pharmacodynam Evaluat Engn Technol Res C, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China.; Tao, R (通讯作者)，Chongqing Med Univ, Bishan Hosp, Dept Hepatobiliary Surg, Chongqing 402760, Peoples R China."

来源：JOURNAL OF NANOBIOTECHNOLOGY

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001064035600001

JCR分区：Q1

影响因子：10.6

年份：2023

卷号：21

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Diabetic wound healing; Nanozymes; Multicatalytic activity; Angiogenesis effect; Photothermal response

摘要："BackgroundThe complex hyperglycemic, hypoxic, and reactive oxygen species microenvironment of diabetic wound leads to vascular defects and bacterial growth and current treatment options are relatively limited by their poor efficacy.ResultsHerein, a functional molecule-mediated copper ions co-assembled strategy was constructed for collaborative treatment of diabetic wounds. Firstly, a functional small molecule 2,5-dimercaptoterephthalic acid (DCA) which has symmetrical carboxyl and sulfhydryl structure, was selected for the first time to assisted co-assembly of copper ions to produce multifunctional nanozymes (Cu-DCA NZs). Secondly, the Cu-DCA NZs have excellent multicatalytic activity, and photothermal response under 808 nm irradiation. In vitro and in vivo experiments showed that it not only could efficiently inhibit bacterial growth though photothermal therapy, but also could catalyze the conversion of intracellular hydrogen peroxide to oxygen which relieves wound hypoxia and improving inflammatory accumulation. More importantly, the slow release of copper ions could accelerate cellular proliferation, migration and angiogenesis, synergistically promote the healing of diabetic wound furtherly.ConclusionsThe above results indicate that this multifunctional nanozymes Cu-DCA NZs may be a potential nanotherapeutic strategy for diabetic wound healing."

基金机构：Not applicable.

基金资助正文：Not applicable.