Evaluation of the correlation of dorsal root ganglia and spinal nerves with clinical symptoms in patients with postherpetic neuralgia using magnetic resonance neurography

作者全名："Cao, Xueqin; Jiao, Bo; Wen, Donglin; Duan, Guangyou; Zhang, Mi; Zhang, Caixia; Wu, Gang; Zhang, Xianwei"

作者地址："[Cao, Xueqin; Jiao, Bo; Zhang, Caixia; Zhang, Xianwei] Huazhong Univ Sci & Technol, Dept Anesthesiol, Hubei Key Lab Geriatr Anesthesia & Perioperat Brai, Tongji Hosp,Tongji Med Coll, Wuhan, Hubei, Peoples R China; [Cao, Xueqin; Jiao, Bo; Zhang, Caixia; Zhang, Xianwei] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan Clin Res Ctr Geriatr Anesthesia, Wuhan, Hubei, Peoples R China; [Wen, Donglin; Wu, Gang] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Radiol, Wuhan, Hubei, Peoples R China; [Duan, Guangyou] Chongqing Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Chongqing, Peoples R China; [Zhang, Mi] Wuhan Univ, Zhongnan Hosp, Dept Anesthesiol, Wuhan, Hubei, Peoples R China"

通信作者："Zhang, XW (通讯作者)，Huazhong Univ Sci & Technol, Dept Anesthesiol, Hubei Key Lab Geriatr Anesthesia & Perioperat Brai, Tongji Hosp,Tongji Med Coll, Wuhan, Hubei, Peoples R China.; Zhang, XW (通讯作者)，Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan Clin Res Ctr Geriatr Anesthesia, Wuhan, Hubei, Peoples R China.; Wu, G (通讯作者)，Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Radiol, Wuhan, Hubei, Peoples R China."

来源：PEERJ

ESI学科分类：Multidisciplinary

WOS号：WOS:001064716600005

JCR分区：Q2

影响因子：2.3

年份：2023

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Postherpetic neuralgia; Dorsal root ganglion; Magnetic resonance neurography; Morphology; Clinical symptoms

摘要："Purpose: To assess changes of dorsal root ganglia (DRG) and spinal nerves in patients with postherpetic neuralgia (PHN), and investigate the correlation between DRG morphology and clinical symptoms in PHN patients using magnetic resonance neurography (MRN). Methods: In this case-control study, forty-nine lesioned DRG in 30 patients and 49 normal DRG in 30 well-matched (age, sex, height, weight) healthy controls were assessed. Clinical symptoms of patients (pain, allodynia, itching, and numbness) were assessed. MRN features (DRG volume (V-DRG), the largest diameter (D-max) of spinal nerves, signal intensity of DRG and spinal nerves (M-value)) were measured in all participants. Multilinear regression analysis was used to evaluate the relationship between the DRG morphology and clinical symptoms in patients. Results: The volume and relative M-value of lesioned DRG in patients were significantly higher than those on the same side of healthy controls (p = 0.013, p < 0.001, respectively). The mean D-max and relative M-value of spinal nerves on the lesioned side were significantly higher than those on the contralateral and same side of healthy controls (p < 0.0001, p = 0.0001, p = 0.0011, p = 0.0053, respectively). No difference was found between the mean VDRG of the lesioned and contralateral sides. Multiple linear regression analysis revealed that disease duration was independent risk factor for the maximum rate of VDRG differences (p = 0.013). Conclusions: DRG and spinal nerves on the lesioned side are swollen during PHN. Disease duration is an independent risk factor for morphological differences in the lesioned DRG of PHN patients. This study provides important guidance for individualized treatments of PHN."

基金机构：　

基金资助正文：