Long-term effects of prenatal magnesium sulfate exposure on nervous system development in preterm-born children

作者全名："Zhou, Le; Liu, Xinghui; Yan, Xiaoli; Liu, Yingwei; Xie, Yao; Sun, Chuntang"

作者地址："[Zhou, Le; Liu, Xinghui; Sun, Chuntang] West China Second Univ Hosp, Sichuan Univ, Obstet & Gynecol Dept, Chengdu, Peoples R China; [Yan, Xiaoli] Army Med Univ, Obstet & Gynecol Dept, Southwest Hosp, Chongqing, Peoples R China; [Liu, Yingwei] Chongqing Med Univ, Obstet & Gynecol Dept, Affiliated Hosp 1, Chongqing, Peoples R China; [Xie, Yao] Sichuan Prov Peoples Hosp, Sichuan Acad Med Sci, Obstet & Gynecol Dept, Chengdu, Peoples R China; [Sun, Chuntang] Sichuan Univ, West China Second Univ Hosp, Obstet & Gynecol Dept, 17 Three Sect South Rd, Chengdu 610041, Peoples R China"

通信作者："Sun, CT (通讯作者)，Sichuan Univ, West China Second Univ Hosp, Obstet & Gynecol Dept, 17 Three Sect South Rd, Chengdu 610041, Peoples R China."

来源：FOOD SCIENCE & NUTRITION

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001064911600001

JCR分区：Q2

影响因子：3.5

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：gray matter volume; magnesium sulfate; preterm birth; structural magnetic resonance imaging; voxel-based morphometry

摘要："This study used structural magnetic resonance imaging to analyze changes in the gray matter volume (GMV) of preterm-born (PTB) and term-born (TB) children to help elucidate the influence of magnesium sulfate treatment on the nervous system development. A total of 51 subjects were recruited, including 28 PTB and 23 TB children. The intelligence scale and MRI scan were completed at the corrected age of 10 to 16 years. A whole-brain voxel-wise analysis tested the main effect of the status (PTB without magnesium, PTB with magnesium, and TB) using a factorial design in SPM8. The mean volumes of the regions that showed significant group effects on the GMV after the FDR correction were extracted in the common space for each subject. Verbal and full-scale intelligence quotient scores were significantly lower for PTB children without magnesium than for TB children; however, the scores of PTB children with magnesium and TB children were almost identical. Compared with TB children, PTB children had significantly reduced left straight gyrus and left inferior frontal gyrus GMVs; however, the volumes of PTB children with magnesium were closer to those of TB children. Changes in the GMV of the left inferior frontal gyrus were significantly correlated with full-scale and verbal intelligence quotient scores, whereas the lower gestational age at the time of mgsou4 treatment led to a larger GMV of the left inferior frontal gyrus. Brain structural abnormalities could exist in PTB children. The GMVs of the left straight gyrus and left inferior frontal gyrus were significantly reduced in these children. The influence of magnesium sulfate treatment was not significant, but the cognitive levels of these children were significantly increased and almost identical to those of TB children. Initiation of magnesium sulfate treatment during gestation is negatively correlated with the left inferior frontal gyrus GMV."

基金机构：We thank all the authors of the studies included. The corresponding author had full access to all data in the study and had final responsibility for the decision to submit it for publication.

基金资助正文：We thank all the authors of the studies included. The corresponding author had full access to all data in the study and had final responsibility for the decision to submit it for publication.