Association between adherence to Eat-Lancet diet and incidence and mortality of lung cancer: A prospective cohort study

作者全名："Xiao, Yi; Peng, Linglong; Xu, Zhiquan; Tang, Yunhao; He, Hongmei; Gu, Haitao; Wang, Yaxu; Xiang, Ling"

作者地址："[Xiao, Yi; Peng, Linglong; Xu, Zhiquan; Tang, Yunhao; He, Hongmei; Gu, Haitao; Wang, Yaxu] Chongqing Med Univ, Affiliated Hosp 2, Dept Gastrointestinal Surg, 288 Tianwen Ave, Chongqing 400010, Peoples R China; [Xiang, Ling] Chongqing Med Univ, Affiliated Hosp 2, Dept Clin Nutr, 288 Tianwen Ave, Chongqing 400010, Peoples R China"

通信作者："Wang, YX (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Gastrointestinal Surg, 288 Tianwen Ave, Chongqing 400010, Peoples R China.; Xiang, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Clin Nutr, 288 Tianwen Ave, Chongqing 400010, Peoples R China."

来源：CANCER SCIENCE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001065109700001

JCR分区：Q1

影响因子：4.5

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：cancer prevention; dietary pattern; Eat-Lancet diet; epidemiology; lung cancer

摘要："Previous research has shown that adhering to the Eat-Lancet diet (ELD) is associated with a lower risk of chronic diseases and mortality. However, the associations between ELD and lung cancer incidence and mortality are unclear. To address this gap, we conducted a prospective cohort study involving 101,755 adults from the Prostate, Lung, Colorectal, and Ovarian (PLCO) trial in the USA. The ELD score was utilized to assess compliance with the ELD, with higher scores indicating greater compliance. We employed Cox regression analyses to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of ELD score with the incidence and mortality of lung cancer and its subtypes. In addition, sensitivity analyses were performed to ensure the robustness of our findings. In total, 1706 cases of lung cancer and 1217 lung cancer-associated deaths were recorded during the study period. Our analysis revealed that higher ELD scores were significantly associated with a reduced incidence (HRQuartile 4 vs. Quartile (1): 0.73; 95% CI: 0.60, 0.89; p(trend) = 0.001) and mortality (HRQuartile 4 vs. Quartile (1): 0.74; 95% CI: 0.59, 0.93; p(trend) = 0.005) of lung cancer in a dose-response manner (all p(nonlinearity) > 0.05). The reliability of these results was supported by sensitivity analyses. Notably, these associations were primarily observed in non-small-cell lung cancer. In conclusion, our findings suggest that adherence to the ELD may be associated with a reduced risk of lung cancer incidence and mortality."

基金机构："Chongqing Science and Technology Commission [CSTB2022NSCQ-MSX1005, cstc2021jcyj-msxmX0112, cstc2021jcyj-msxmX0153]; Kuanren Talents Project of the Second Affiliated Hospital of Chongqing Medical University [kryc-yq-2110]"

基金资助正文："Chongqing Science and Technology Commission, Grant/Award Number: CSTB2022NSCQ-MSX1005, cstc2021jcyj-msxmX0112 and cstc2021jcyj-msxmX0153; Kuanren Talents Project of the Second Affiliated Hospital of Chongqing Medical University, Grant/ Award Number: kryc-yq-2110."