"Hair and cord blood element levels and their relationship with air pollution, dietary intake, gestational diabetes mellitus, and infant neurodevelopment"

作者全名："Xia, Yin-Yin; de Seymour, Jamie, V; Yang, Xiao-Jia; Zhou, Lin-Wei; Liu, Yue; Yang, Yang; Beck, Kathryn L.; Conlon, Cathryn A.; Mansell, Toby; Novakovic, Boris; Saffery, Richard; Han, Ting-Li; Zhang, Hua; Baker, Philip N."

作者地址："[Xia, Yin-Yin; Zhou, Lin-Wei; Liu, Yue; Yang, Yang; Zhang, Hua] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China; [Xia, Yin-Yin; Yang, Xiao-Jia; Liu, Yue] Chongqing Med Univ, Res Ctr Med & Social Dev, Innovat Ctr Social Risk Governance Hlth, Sch Publ Hlth,Dept Occupat & Environm Hyg, Chongqing, Peoples R China; [Xia, Yin-Yin; Liu, Yue; Yang, Yang; Han, Ting-Li; Zhang, Hua] Chongqing Med Univ, Mass Spectrometry Ctr Maternal Fetal Med, Chongqing, Peoples R China; [de Seymour, Jamie, V; Beck, Kathryn L.; Conlon, Cathryn A.] Massey Univ, Coll Hlth, Sch Sport Exercise & Nutr, Auckland, New Zealand; [Mansell, Toby; Novakovic, Boris; Saffery, Richard] Murdoch Childrens Res Inst, Mol Immun, Melbourne, Vic, Australia; [Mansell, Toby; Novakovic, Boris; Saffery, Richard] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia; [Han, Ting-Li] Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynaecol, Chongqing, Peoples R China; [Han, Ting-Li] Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China; [Baker, Philip N.] Univ Leicester, Coll Life Sci, Leicester, England; [Han, Ting-Li] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing 400016, Peoples R China; [Zhang, Hua] Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynaecol, Chongqing 400016, Peoples R China"

通信作者："Han, TL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing 400016, Peoples R China.; Zhang, H (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynaecol, Chongqing 400016, Peoples R China."

来源：CLINICAL NUTRITION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001065111400001

JCR分区：Q1

影响因子：6.6

年份：2023

卷号：42

期号：10

开始页：1875

结束页：1888

文献类型：Article

关键词：Hair elements; Inductively coupled plasma-mass; spectrometry; Gestational diabetes mellitus; Infant neurodevelopment; Air pollutant exposures; Maternal diet

摘要："Background & aims: Exposure to a range of elements, air pollution, and specific dietary components in pregnancy has variously been associated with gestational diabetes mellitus (GDM) risk or infant neurodevelopmental problems. We measured a range of pregnancy exposures in maternal hair and/or infant cord serum and tested their relationship to GDM and infant neurodevelopment.Methods: A total of 843 pregnant women (GDM = 224, Non-GDM = 619) were selected from the Complex Lipids in Mothers and Babies cohort study. Forty-eight elements in hair and cord serum were quantified using inductively coupled plasma-mass spectrometry analysis. Binary logistic regression was used to estimate the associations between hair element concentrations and GDM risk, while multiple linear regression was performed to analyze the relationship between hair/cord serum elements and air pollutants, diet exposures, and Bayley Scales of infant neurodevelopment at 12 months of age. Results: After adjusting for maternal age, BMI, and primiparity, we observed that fourteen elements in maternal hair were associated with a significantly increased risk of GDM, particularly Ta (OR = 9.49, 95% CI: 6.71, 13.42), Re (OR = 5.21, 95% CI: 3.84, 7.07), and Se (OR = 5.37, 95% CI: 3.48, 8.28). In the adjusted linear regression model, three elements (Rb, Er, and Tm) in maternal hair and infant cord serum were negatively associated with Mental Development Index scores. For dietary exposures, elements were positively associated with noodles (Nb), sweetened beverages (Rb), poultry (Cs), oils and condiments"

基金机构："National Natural Science Foundation of China [81871185, 81971406, 82271715]; 111 Project [Yuwaizhuan (2016)32]; Chongqing Science and Technology Commission [CSTC2021JCYJ-MSXMX0213, CSTB2022NSCQ-MSX1679, CSTB2022NSCQ-MSX1680]; Chongqing Municipal Education Commission [KJZD-K202100407]; Chongqing Health Commission and Chongqing Science amp; Technology Commission [2021MSXM121, 2020MSXM101]; Smart Medicine Research Project of Chongqing Medical University [ZHYX202103]; Senior Medical Talents Program of Chongqing for Young and Middle-aged [19/804]; Kuanren Talents Programs of Second Affiliated Hospital of Chongqing Medical University; joint Health Research Council New Zealand-National Science Foundation of China Biomedical Research Fund [[2022] 15]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (No. 81871185, 81971406, 82271715), The 111 Project (Yuwaizhuan (2016)32), Chongqing Science and Technology Commission (CSTC2021JCYJ-MSXMX0213, CSTB2022NSCQ-MSX1679, CSTB2022NSCQ-MSX1680), Chongqing Municipal Education Commission (KJZD-K202100407), Chongqing Health Commission and Chongqing Science & Technology Commission (2021MSXM121, 2020MSXM101), Smart Medicine Research Project of Chongqing Medical University (No. ZHYX202103), Senior Medical Talents Program of Chongqing for Young and Middle-aged [2022] 15, Kuanren Talents Programs of Second Affiliated Hospital of Chongqing Medical University, and a joint Health Research Council New Zealand-National Science Foundation of China Biomedical Research Fund (19/804)."