"Enantioselective Alkynylation of Pyrazole-4,5-diones with Terminal Alkynes Catalyzed by Copper/PyBisulidine"

作者全名："Chai, Yu; Chen, Peng; Wu, Ruoran; Zhou, Junyu; Ou, Jianhua; Min, Yan; Wang, Haoting; Zhang, Dong; Zhou, Hui; Liu, Yan; Zhou, Jing"

作者地址："[Chai, Yu; Chen, Peng; Wu, Ruoran; Zhou, Junyu; Ou, Jianhua; Min, Yan; Wang, Haoting; Zhang, Dong; Zhou, Hui; Liu, Yan; Zhou, Jing] Chongqing Med Univ, Chongqing Res Ctr Pharmaceut Engn, Coll Pharm, Chongqing 400016, Peoples R China"

通信作者："Liu, Y; Zhou, J (通讯作者)，Chongqing Med Univ, Chongqing Res Ctr Pharmaceut Engn, Coll Pharm, Chongqing 400016, Peoples R China."

来源：JOURNAL OF ORGANIC CHEMISTRY

ESI学科分类：CHEMISTRY

WOS号：WOS:001065406300001

JCR分区：Q1

影响因子：3.3

年份：2023

卷号：88

期号：19

开始页：13645

结束页：13654

文献类型：Article

关键词：　

摘要："A copper/PyBisulidine-catalyzed enantioselective alkynylation of electrophilic pyrazole-4,5-dione with terminal alkynes has been developed. Chiral tertiary propargylic alcohols bearing the pyrazolone motif were prepared with yields (up to 99%) and enantioselectivities (up to 99% ee). The prominent feature of this protocol includes its mild reaction conditions and good stereoselectivities. The nonlinear effect study showed that the catalytically active specie was a monomeric catalyst and that the excess copper activated the alkynes through the p-system."

基金机构：National Natural Science Foundation of China [21672031]; Natural Science Foundation of Chongqing [cstc2019jcyj-msxmX0034]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN201900437]

基金资助正文："The work was supported by the National Natural Science Foundation of China (21672031), the Natural Science Foundation of Chongqing (cstc2019jcyj-msxmX0034), and the Science and Technology Research Program of Chongqing Municipal Education Commission (KJQN201900437)."