Vitamin C inhibits the growth of colorectal cancer cell HCT116 and reverses the glucose-induced oncogenic effect by downregulating the Warburg effect

作者全名："Yu, Chang; Min, Su; Lv, Feng; Ren, Li; Yang, You; Chen, Lihao"

作者地址："[Yu, Chang; Min, Su; Lv, Feng; Ren, Li; Yang, You; Chen, Lihao] Chongqing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Min, S (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：MEDICAL ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001065537700001

JCR分区：Q2

影响因子：2.8

年份：2023

卷号：40

期号：10

开始页：　

结束页：　

文献类型：Article

关键词：Vitamin C; Cancer; Glucose; Warburg effect; Nutritional support

摘要："Malnutrition caused by insufficient nutritional supply may significantly hinder the quality of life among cancer patients. Sugar provides energy and nutritional support, but it also promotes cancer growth. Warburg effect is the reprogrammed glucose metabolic mode of cancer cells that meets the intensified ATP demand and biosynthesis. Vitamin C (VC) has anti-tumor effect. However, the relationship between cytotoxicity of VC on cancer cells and Warburg effect remains elusive, the effect of VC on glucose-induced oncogenic effect is also unclear. Based on colorectal cancer cell HCT116, our finding revealed that the discrepant oncogenic effect of different sugar is closely related to the intensification of Warburg effect, with glucose being the potent oncogenic component. Notably, as a potential Warburg effect inhibitor, VC suppressed cancer growth in a concentration-dependent manner and further reversed the glucose-induced oncogenic effect. Furthermore, VC protected tumor-bearing mice from insulin sensitivity impairment and inflammatory imbalance. These findings imply that VC might be a useful adjuvant treatment for cancer patients seeking to optimize nutritional support."

基金机构：Medical Research Project of Chongqing Science and Technology Commission and Health Commission [2021MSXM079]; University-level Cooperation Project of Chongqing Medical University [X1-2174]

基金资助正文：& nbsp;This work was supported by the Medical Research Project of Chongqing Science and Technology Commission and Health Commission (Grand No. 2021MSXM079) and the University-level Cooperation Project of Chongqing Medical University (Grand No. X1-2174).