"Anesthetic drug concentrations and placental transfer rate in fetus between term and preterm infants, twins, and singletons"

作者全名："Liu, Hao; Miao, Jing-Kun; Cai, Meng; Gan, Lin; Zhao, Hui-Qing; Lei, Xiao-Feng; Yu, Jin"

作者地址："[Liu, Hao; Miao, Jing-Kun] Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Dept Pediat, Chongqing, Peoples R China; [Cai, Meng; Gan, Lin; Zhao, Hui-Qing; Lei, Xiao-Feng; Yu, Jin] Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Dept Anesthesiol, Women & Childrens Hosp, Chongqing, Peoples R China"

通信作者："Yu, J (通讯作者)，Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Dept Anesthesiol, Women & Childrens Hosp, Chongqing, Peoples R China."

来源：FRONTIERS IN PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001065555800001

JCR分区：Q1

影响因子：4.4

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：cesarean section; general anesthesia; preterm; twins; drug concentration

摘要："Objective: This study aims to determine the drug concentration of etomidate, remifentanil, and rocuronium bromide for general anesthesia in fetus as well as the placental transport rate between term and preterm delivery, twins, and singleton.Study design: Sixty parturients with 72 fetuses undergoing cesarean section under general anesthesia were included. According to whether the fetus was a twin or premature, parturients were divided into Group I (term singleton), Group II (premature singleton), Group III (term twins), and Group IV (premature twins). The preoperative demographic characteristics and laboratory examination of parturients, hemodynamic indicators, the Apgar score of neonates at 1, 5, and 10 min after delivery and at specific assigned values, umbilical artery blood gas analysis results, neonatal weight, and resuscitative measures were recorded. Anesthetic drug concentrations in maternal arterial (MA), umbilical arterial (UA), and umbilical venous (UV) blood were detected by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS/MS).Result: No significant differences were observed in the concentrations of etomidate, remifentanil, and rocuronium bromide in MA, UV, and UA blood, or in the UV/MA and UA/UV ratios between term and preterm infants, twins, and singletons. Moreover, there was no variation in the anesthetic drug concentration among each pair of twins. Additionally, no correlation was found between the neonatal weight and the plasma concentrations of anesthetic drugs in UV and UA blood, except for remifentanil in UA blood.Conclusion: Preterm or twin deliveries do not affect the neonatal concentration of etomidate, remifentanil, and rocuronium bromide used in general anesthesia for cesarean sections.Clinical Trial Registration: www.chictr.org.cn, identifier ChiCTR2100046547"

基金机构：Natural Science Foundation of Chongqing of China [cstc2021jcyj-msxmX0763]; Institutional Research Grants of Chongqing Health Center for Women and Children [2021YJMS03]; National Key Clinical Specialty Construction Project (Obstetrics and Gynecology)

基金资助正文："This study was supported by Natural Science Foundation of Chongqing of China (No. cstc2021jcyj-msxmX0763), Institutional Research Grants of Chongqing Health Center for Women and Children (No. 2021YJMS03) and National Key Clinical Specialty Construction Project (Obstetrics and Gynecology)."