Identification of immune-related signature with prognosis in children with stage 4 and 4S neuroblastoma

作者全名："Cao, Lijian; Liu, Qingqing; Ma, Yue; Wang, Shan"

作者地址："[Cao, Lijian; Liu, Qingqing; Ma, Yue; Wang, Shan] Chongqing Med Univ, Dept Pediat Surg Oncol, Key Lab Child Dev & Disorders, Chongqing Key Lab Pediat,Childrens Hosp,Minist Edu, Chongqing 400014, Peoples R China; [Cao, Lijian; Liu, Qingqing; Ma, Yue; Wang, Shan] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing 400014, Peoples R China"

通信作者："Wang, S (通讯作者)，Chongqing Med Univ, Dept Pediat Surg Oncol, Key Lab Child Dev & Disorders, Chongqing Key Lab Pediat,Childrens Hosp,Minist Edu, Chongqing 400014, Peoples R China.; Wang, S (通讯作者)，Natl Clin Res Ctr Child Hlth & Disorders, Chongqing 400014, Peoples R China."

来源：CLINICAL & TRANSLATIONAL ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001066008000001

JCR分区：Q2

影响因子：2.8

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Neuroblastoma; Signature; Prognosis; Immune cell infiltration

摘要："ObjectiveSpontaneous regression of tumors is an attractive phenomenon that most commonly occurs in stage 4S neuroblastoma (NB). However, the mechanism underlying this phenomenon remains unclear.MethodsDatasets correlated with NB were downloaded from online public databases, the differentially expressed genes (DEGs) between stage 4 and 4S associated with immunity were identified, and functional enrichment analysis was utilized to explore the potential functions and signaling pathways of these DEGs. In addition, based on these DEGs, a prognostic signature was constructed and validated, and differences in immune cell infiltration were analyzed.ResultsA total of 13 DEGs were finally identified, and functional enrichment analysis revealed that these DEGs were primarily enriched in the positive regulation of neuron differentiation and TGF-& beta; signaling pathway. The signature successfully stratifies patients into two risk score groups and performs well in judging prognosis and predicting overall survival time. In addition, the prognostic value of the risk score calculated by the signature was independent of clinical factors. The results of immune cell infiltration showed that patients with a high infiltration of resting CD4 + memory T cells had a better prognosis, while plasma cells had a worse prognosis.ConclusionThe results of the functional enrichment analysis of these identified DEGs suggested that these DEGs may be related to spontaneous regression of NB. In addition, the prognostic signature has the potential to create new risk stratification in patients with NB."

基金机构："Key Project of ""Research on Prevention and Control of Major Chronic Non-Communicable Diseases""; Ministry of Science and Technology of the People's Republic of China, National Key R amp; D Program of China [2018YFC1313000, 2018YFC1313004]"

基金资助正文："This work was supported by Part of research grants from the Key Project of ""Research on Prevention and Control of Major Chronic Non-Communicable Diseases"", the Ministry of Science and Technology of the People's Republic of China, National Key R & amp; D Program of China (No. 2018YFC1313000, 2018YFC1313004)."