Increased cortical lesion load contributed to pathological changes beyond focal lesion in cortical gray matter of multiple sclerosis: a diffusion kurtosis imaging analysis

作者全名："Zhu, Qiyuan; Yan, Zichun; Shi, Zhuowei; Luo, Dan; Ding, Shuang; Chen, Xiaoya; Li, Yongmei"

作者地址："[Zhu, Qiyuan; Yan, Zichun; Shi, Zhuowei; Luo, Dan; Chen, Xiaoya; Li, Yongmei] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Ding, Shuang] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Key Lab Child Dev & Disorders, Chongqing Key Lab Pediat,Minist Educ,Dept Radiol,C, Chongqing 400014, Peoples R China; [Li, Yongmei] 1 Youyi Rd, Chongqing, Peoples R China"

通信作者："Li, YM (通讯作者)，1 Youyi Rd, Chongqing, Peoples R China."

来源：CEREBRAL CORTEX

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001066201300001

JCR分区：Q2

影响因子：2.9

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：multiple sclerosis; diffusion kurtosis imaging; cortical gray matter; cortical lesion

摘要："Biomarkers specific to cortical gray matter (cGM) pathological changes of multiple sclerosis (MS) are desperately needed to better understand the disease progression. The cGM damage occurs in cortical lesion (CL) and normal-appearing cGM (NAcGM) areas. While the association between CL load and cGM damage has been reported, little is known about how different CL types, i.e. intracortical lesion (ICL) and leukocortical lesion (LCL) would be associated with cGM damage. In our study, relapsing-remitting MS patients and healthy controls were divided into 4 groups according to CL load level. NAcGM diffusion kurtosis imaging (DKI)/diffusion tensor imaging (DTI) values and cGM volume (cGMV) were used to characterize the pathological changes in cGM. Univariate general linear model was used for group comparisons and stepwise regression analysis was used to assess the effects of ICL volume and LCL volume on NAcGM damage. We found peak values in DKI/DTI values, cGMV and neuropsychological scores in high CL load group. Kurtosis fractional anisotropy (KFA) was the most sensitive in characterizing NAcGM damage, and LCL volume related more to NAcGM damage. Our findings suggested KFA could become a surrogate biomarker to cGM damage, and LCL might be the main factor in whole brain NAcGM damage."

基金机构：All authors would like to thank all the subjects who participated in this study.

基金资助正文：All authors would like to thank all the subjects who participated in this study.