Relationship between serum iron and blood eosinophil counts in asthmatic adults: data from NHANES 2011-2018

作者全名："Wen, Jun; Wang, Changfen; Xia, Jing; Giri, Mohan; Guo, Shuliang"

作者地址："[Wen, Jun; Giri, Mohan; Guo, Shuliang] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing, Peoples R China; [Wang, Changfen] Chongqing Med Univ, Dept Ultrasonog, Affiliated Hosp 1, Chongqing, Peoples R China; [Xia, Jing] Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 3, Chongqing, Peoples R China"

通信作者："Guo, SL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001066947000001

JCR分区：Q1

影响因子：5.7

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：serum iron; eosinophil; asthma; National Health And Nutrition Examination Survey (NHANES); XGBoost; machine learning

摘要："BackgroundSo far, quite a few studies have revealed that systemic iron levels are related to asthmatic inflammatory reactions. And most studies have focused on the correlation between systemic iron levels and asthma, with inconsistent findings. Yet, few studies have investigated the connection between serum iron and blood eosinophil counts. Hence, we have explored the connection between serum iron and blood eosinophil counts in asthmatics by utilizing data from NHANES.MethodsA total of 2549 individuals were included in our study after screening NHANES participants from 2011 to 2018. The linear regression model and XGBoost model were used to discuss the potential connection. Linear or nonlinear association was further confirmed by the generalized additive model and the piecewise linear regression model. And we also performed stratified analyses to figure out specific populations.ResultsIn the multivariable linear regression models, we discovered that serum iron levels were inversely related to blood eosinophil counts in asthmatic adults. Simultaneously, we found that for every unit increase in serum iron (umol/L), blood eosinophil counts reduced by 1.41/uL in model 3, which adjusted for all variables excluding the analyzed variables. Furthermore, the XGBoost model of machine learning was applied to assess the relative importance of chosen variables, and it was determined that vitamin C intake, age, vitamin B12 intake, iron intake, and serum iron were the five most important variables on blood eosinophil counts. And the generalized additive model and piecewise linear regression model further verify this linear and inverse association.ConclusionOur investigation discovered that the linear and inverse association of serum iron with blood eosinophil counts in asthmatic adults, indicating that serum iron might be related to changes in the immunological state of asthmatics. Our work offers some new thoughts for next research on asthma management and therapy. Ultimately, we hope that more individuals become aware of the role of iron in the onset, development, and treatment of asthma."

基金机构："Chongqing Talents, Teachers and Masters (SG).; Chongqing Talents, Teachers and Masters (SG)"

基金资助正文："The NHANES protocol was approved by the NCHS Research Ethics Review Board.r Chongqing Talents, Teachers and Masters (SG)."