Prognostic significance of psoas muscle index in male hepatocellular carcinoma patients treated with immune checkpoint inhibitors and tyrosine kinase inhibitors

作者全名："Luo, Ning; Li, Hu; Luo, Yindeng; Hu, Peng; Liang, Luwen; Zhang, Rong; Zhang, Dazhi; Cai, Dachuan; Kang, Juan"

作者地址："[Luo, Ning; Li, Hu; Hu, Peng; Liang, Luwen; Zhang, Rong; Zhang, Dazhi; Cai, Dachuan; Kang, Juan] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing, Peoples R China; [Luo, Yindeng] Chongqing Med Univ, Affiliated Hosp 2, Dept Radiol, Chongqing, Peoples R China; [Kang, Juan] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, 288 Tianwen Ave, Chongqing 401336, Peoples R China"

通信作者："Kang, J (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, 288 Tianwen Ave, Chongqing 401336, Peoples R China."

来源：HUMAN VACCINES & IMMUNOTHERAPEUTICS

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001067209800001

JCR分区：Q2

影响因子：4.1

年份：2023

卷号：19

期号：2

开始页：　

结束页：　

文献类型：Article

关键词：Psoas muscle index; hepatocellular carcinoma; immune checkpoint inhibitors; tyrosine kinase inhibitors; nutrition

摘要："Currently, the relationship between nutritional indices and the prognosis of hepatocellular carcinoma (HCC) patients treated with immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs) remains unclear. This study aims to investigate the prognostic value of psoas muscle index (PMI), prognostic nutritional index (PNI), body mass index (BMI), and geriatric nutritional risk index (GNRI) in HCC patients treated with ICIs combined with TKIs. A total of 124 male patients with HCC were included in this study. PNI, PMI, BMI, and GNRI were calculated at the beginning of treatment. The Cox proportional hazards model was used to analyze the effect of various variables. In the univariate analysis, PMI, PNI, GNRI, and ALB were found to impact the outcomes of the patients at different follow-up times. However, the predictive value of these nutritional indices was eliminated when established risk factors were considered. In the multivariate analysis that only included nutrition-related indicators, PMI emerged as an independent prognostic factor for 1-year treatment outcomes. The group with low PMI (& LE;5.5409 cm2/m2) was found to have a higher risk of death at one year and at the end of the follow-up period."

基金机构："General Project of Chongqing Natural Science Foundation [cstc2020jcyj-msxmX0015]; Future Medical Youth Innovation Team of Chongqing Medical University [W0027]; Remarkable Innovation-Clinical Research Project, The Second Affiliated Hospital of Chongqing Medical University; First batch of key Disciplines on Public Health in Chongqing, Health Commission of Chongqing, China"

基金资助正文："This research was funded by General Project of Chongqing Natural Science Foundation [cstc2020jcyj-msxmX0015], Future Medical Youth Innovation Team of Chongqing Medical University [W0027] and Remarkable Innovation-Clinical Research Project, The Second Affiliated Hospital of Chongqing Medical University and The First batch of key Disciplines on Public Health in Chongqing, Health Commission of Chongqing, China."