Evaluation of Nocturnal Symptoms in Chinese Parkinson's Disease Patients Based on the PDSS-2 Scale: A Multicenter Cross-Sectional Study

作者全名："Su, Wen; Huang, Pei; Ma, Xinxin; Shang, Huifang; Ye, Qinyong; Cheng, Oumei; Chan, Piu; Liu, Chunfeng; Liu, Weiguo; Tang, Beisha; Wang, Lijuan; Zhang, Baorong; Wang, Tao; Shao, Ming; Xie, Anmu; Chen, Xianwen; Zhu, Xiaodong; Wang, Jian; Tao, Enxiang; Chen, Shengdi; Chen, Haibo"

作者地址："[Su, Wen; Huang, Pei; Ma, Xinxin; Chen, Haibo] Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Gerontol,Dept Neurol, Beijing, Peoples R China; [Shang, Huifang] Sichuan Univ, Dept Neurol, West China Hosp, Chengdu, Sichuan, Peoples R China; [Ye, Qinyong] Fujian Med Univ, Dept Neurol, Union Hosp, Fuzhou, Fujian, Peoples R China; [Cheng, Oumei] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [Chan, Piu] Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China; [Liu, Chunfeng] Soochow Univ, Affiliated Hosp 2, Dept Neurol, Suzhou, Jiangsu, Peoples R China; [Liu, Weiguo] Nanjing Med Univ, Affiliated Brain Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China; [Tang, Beisha] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha, Peoples R China; [Wang, Lijuan] Guangdong Prov Peoples Hosp, Dept Neurol, Guangzhou, Guangdong, Peoples R China; [Zhang, Baorong] Zhejiang Univ, Affiliated Hosp 2, Internal Med Neurol, Hangzhou, Zhejiang, Peoples R China; [Wang, Tao] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Neurol, Union Hosp, Wuhan, Hubei, Peoples R China; [Shao, Ming] Guangzhou Med Univ, Affiliated Brain Hosp, Dept Neurol, Guangzhou, Guangdong, Peoples R China; [Xie, Anmu] Qingdao Univ, Affiliated Hosp, Dept Neurol, Qingdao, Shandong, Peoples R China; [Chen, Xianwen] Anhui Med Univ, Affiliated Hosp 1, Dept Neurol, He Fei Shi, Anhui, Peoples R China; [Zhu, Xiaodong] Tianjin Med Univ Gen Hosp, Dept Neurol, Tianjin, Peoples R China; [Wang, Jian] Fudan Univ, Dept & Inst Neurol, Huashan Hosp, Shanghai, Peoples R China; [Tao, Enxiang] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Neurol, Guangzhou, Guangdong, Peoples R China; [Chen, Shengdi] Shanghai Jiao Tong Univ, Sch Med, Dept Neurol, Shanghai, Peoples R China; [Chen, Shengdi] Shanghai Jiao Tong Univ, Ruijin Hosp, Inst Neurol, Shanghai, Peoples R China"

通信作者："Chen, HB (通讯作者)，Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Gerontol,Dept Neurol, Beijing, Peoples R China.; Chen, SD (通讯作者)，Shanghai Jiao Tong Univ, Sch Med, Dept Neurol, Shanghai, Peoples R China.; Chen, SD (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Inst Neurol, Shanghai, Peoples R China."

来源：JOURNAL OF PARKINSONS DISEASE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001067501400016

JCR分区：Q2

影响因子：4

年份：2023

卷号：13

期号：6

开始页：1063

结束页：1073

文献类型：Article

关键词：Parkinson's disease; nocturnal symptoms; quality of life; PDSS-2; associated factors

摘要："Background: Nocturnal symptoms have a significant effect on the quality of life in Parkinson's disease (PD) patients. Objective: This study aimed to investigate the prevalence and associated factors of nocturnal symptoms in Chinese PD patients. Methods: This multicenter cross-sectional study included 1,500 patients with primary PD from 18 centers in China was carried out between February 2019 and February 2020. Questionnaires including Parkinson's disease sleep scale 2 (PDSS-2), Parkinson's disease questionnaire 8 (PDQ-8), Beck depression inventory (BDI), and generalized anxiety disorder scale 7 (GAD-7) were used to assess nocturnal symptoms, quality of life, depression, and anxiety. Results: Among 1,500 Chinese PD patients, 576 (38.4%) reported nocturnal symptoms. Of them, 59.2% were older than 65 years. The PDQ-8 total score was higher in patients with nocturnal symptoms (p < 0.01). Moderate and severe depression was reported more often in patients with nocturnal symptoms (p < 0.01), and the occurrence and severity of anxiety were higher as well (p < 0.01). Longer disease duration and higher Hoehn-Yahr (HY) stage were independently associated with nocturnal symptoms (p < 0.01). Education level, depression, disease course, HY stage, and nocturnal symptoms were related to the quality of life in Chinese PD patients (p < 0.01). Conclusion: Our study found that 38.4% of Chinese PD patients have nocturnal symptoms, even in early and mid-stage PD. Nocturnal symptoms were associated with worse quality of life and higher incidences of depression and anxiety. Nocturnal symptoms should be included in the assessment and care plan, especially in patients with longer disease courses and higher HY stages."

基金机构：UCB Pharma; Chinese Society of Gerontology and Geriatrics; Parkinson's Disease and Movement Disorders Group of the Neurology Society of the Chinese Medical Association

基金资助正文："This study was funded by UCB Pharma. The sponsor was the Chinese Society of Gerontology and Geriatrics, and the co-sponsor was the Parkinson's Disease and Movement Disorders Group of the Neurology Society of the Chinese Medical Association."