Risk of Atrial Fibrillation Following Left Bundle Branch Area Pacing versus Right Ventricular Pacing and Biventricular Pacing: A Systematic Review and Meta-Analysis

作者全名："Liu, Bing; Dai, Wenlong; Lou, Yake; Li, Yulin; Wu, Yongquan; Du, Jie"

作者地址："[Liu, Bing; Dai, Wenlong; Li, Yulin; Wu, Yongquan; Du, Jie] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China; [Lou, Yake] Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing 400010, Peoples R China; [Du, Jie] Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing 100029, Peoples R China"

通信作者："Du, J (通讯作者)，Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China.; Du, J (通讯作者)，Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing 100029, Peoples R China."

来源：REVIEWS IN CARDIOVASCULAR MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001067770500009

JCR分区：Q3

影响因子：1.9

年份：2023

卷号：24

期号：8

开始页：　

结束页：　

文献类型：Review

关键词：atrial fibrillation; left bundle branch area pacing; left bundle branch pacing; biventricular pacing; right ventricular pacing; meta-analysis; systematic review

摘要："Background: Left bundle branch pacing (LBBP) is a relatively novel physiological pacing strategy with better electrocardiogram characteristics and pacing parameters than other pacing strategies. At present, no meta-analysis or systematic review has examined the risk of atrial fibrillation (AF) after LBBP compared to other pacing strategies. Methods: We searched the PubMed, Embase, and Cochrane Library databases from inception through September 18, 2022 to identify relevant studies reporting AF incidence rates after LBBP. The incidence of AF following LBBP and that associated with other pacing strategies were extracted and summarized for the meta-analysis. We used odds ratios (ORs) and 95% confidence intervals (CIs) as summary estimates. Results: Five studies with 1144 participants were included. The pooled rate of AF was 3.7% (95% CI, 0.8%-8.0%) in the LBBP group and 15.5% (95% CI: 9.6%-22.4%) in the other pacing strategies (right ventricular pacing [RVP] and biventricular pacing [BVP]). Compared with other pacing strategies, LBBP was associated with a lower AF risk (OR, 0.33; 95% CI: 0.22-0.51, I2 = 0.0%; p = 0.485). Similar results were observed for LBBP when compared with RVP (OR: 0.33, 95% CI: 0.22-0.51, I2 = 0.0%, p = 0.641) and BVP (OR: 0.47, 95% CI: 0.01-15.22, I2 = 60.4%, p = 0.112). Conclusions: Compared with BVP and RVP, LBBP was associated with a significantly lower risk of AF. However, further large-sample randomized controlled trials are needed to confirm that LBBP is superior to other pacing strategies in reducing AF risk."

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