Antimicrobial effect of Streptococcus salivarius outer membrane-coated nanocomplexes against Candida albicans and oral candidiasis

作者全名："Ye, Jiajia; Liang, Wen; Wu, Lang; Guo, Rongjuan; Wu, Wei; Yang, Deqin; Chen, Liang"

作者地址："[Ye, Jiajia; Liang, Wen; Wu, Lang; Guo, Rongjuan; Chen, Liang] Chongqing Med Univ, Stomatol Hosp, Chongqing 401147, Peoples R China; [Ye, Jiajia; Chen, Liang] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China; [Liang, Wen; Wu, Lang; Guo, Rongjuan; Chen, Liang] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China; [Wu, Wei] Chongqing Univ, Bioengn Coll, Chongqing 400044, Peoples R China; [Wu, Wei] Chongqing Univ, Bioengn Coll, 174 Shazhengjie, Chongqing 400044, Peoples R China; [Yang, Deqin; Chen, Liang] Chongqing Med Univ, Stomatol Hosp, 426 Songshi North Rd, Chongqing 401147, Peoples R China"

通信作者："Wu, W (通讯作者)，Chongqing Univ, Bioengn Coll, 174 Shazhengjie, Chongqing 400044, Peoples R China.; Yang, DQ; Chen, L (通讯作者)，Chongqing Med Univ, Stomatol Hosp, 426 Songshi North Rd, Chongqing 401147, Peoples R China."

来源：MATERIALS & DESIGN

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001067936000001

JCR分区：Q1

影响因子：7.6

年份：2023

卷号：233

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Candida albicans; Cell membranes; Streptococcus salivarius; Biofilms; Nanoparticles

摘要："Oral mucosal infection, especially oral candidiasis, is currently the most common oral mucosal disease. Traditional drug treatment regimens have difficulty adhering to mucous membranes, coupled with the unique anatomical and physiological characteristics of the oral cavity, thus reducing drug availability and limiting the effective time of drug action. Inspired by cell membrane-coated nanoparticles, this study aimed to construct a bionic adherent oral mucosal drug delivery system and investigated its therapeutic potential for oral candidiasis. The system was obtained by encapsulating Streptococcus salivarius K12 membranes on triclosan-loaded PLGA nanoparticles using an extrusion method. The constructed nanocomplexes (K12/TCS@PLGA-NPs) inherited the properties of the source cell membrane, bionically adhering to the oral mucosa and binding to the candida albicans hypha. Our in vitro and in vivo experiments have confirmed that K12/TCS@PLGA-NPs nanocomplexes significantly inhibits the formation of C. albicans biofilms and the development of oral candidiasis by enhancing the accumulation of drugs in lesions, optimizing drug efficacy. Furthermore, the biomimetic nanocomplexes could be considered safe and effective drug delivery systems, which hold considerable therapeutic promise for oral mucosal infections including candidiasis."

基金机构："Natural Science Foundation of China [2021XM3062]; Chongqing Postdoctoral Science Foundation [CSTB2022NSCQ-MSX0128]; Natural Science Foundation of Chongqing [W0034]; Program for Youth Innovation in Future Medicine, Chongqing Medical University; [31970783]"

基金资助正文："This research was supported by Natural Science Foundation of China (31970783) , Chongqing Postdoctoral Science Foundation (2021XM3062) , Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0128) and Program for Youth Innovation in Future Medicine, Chongqing Medical University (W0034) ."