Evaluation of Platelet Distribution Width as an Early Predictor of Acute Kidney Injury in Extensive Burn Patients

作者全名："Jiang, Ming; Zhang, Qingrong; Zhang, Chuwei; Li, Zihan; Li, Qiqi; Qu, Xun; Zhang, Yi; Hu, Kesu"

作者地址："[Jiang, Ming; Zhang, Chuwei; Li, Zihan; Li, Qiqi; Qu, Xun; Zhang, Yi; Hu, Kesu] Nantong Univ, Dept Burn & Plast Surg, Affiliated Hosp, Nantong, Jiangsu, Peoples R China; [Jiang, Ming; Zhang, Chuwei; Li, Zihan; Li, Qiqi] Nantong Univ, Med Sch, Nantong, Jiangsu, Peoples R China; [Zhang, Qingrong] Third Mil Med Univ, Army Med Univ, Chongqing, Peoples R China"

通信作者："Hu, KS (通讯作者)，Nantong Univ, Dept Burn & Plast Surg, Affiliated Hosp, Nantong, Jiangsu, Peoples R China."

来源：EMERGENCY MEDICINE INTERNATIONAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001068018400001

JCR分区：Q3

影响因子：1.2

年份：2023

卷号：2023

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Background. Te extensive burns devastate trauma. Te research was designed to analyse the predictive value of early platelet (PLT) indices on the development of acute kidney injury (AKI) after severe burns. Methods and Results. 186 patients with extensive burns (burn area =30%) were eventually involved. Multivariate analyses pointed out that platelet distribution width (PDW) in the frst 24 h after admission was an independent risk factor for AKI, severe AKI, and RRT requirement in patients with severe burns, and AKI risk showed an increase of 30.9% per increase of 1% in PDW (OR =1.309, CI, 1.075-1.594, and P= 0.007). It was found that the area under the ROC curve (AUC) of PDW predicting AKI was 0.735 and that the AUC value was 0.81 for AKI after combining PDW and blood urea nitrogen (BUN). Based on the cut-off value PDW = 17.7%, patients were divided into high-(PDW =17.7%) and low-risk (PDW <17.7%) groups. In the KM analysis, there was a higher cumulative incidence of AKI if patients were in a high-risk group (in 30 days); and the stages of AKI showed a linear upward trend (chi-square test for linear trend P < 0.001) as there was an increase in the risk level. Conclusion. Te PDW level in the early stage serves as an important risk factor for AKI, severe AKI, and RRT requirement in extensive burns. When PDW >17.7%, burn patients are not only ata higher risk for AKI but may also have higher AKI severity. Due to low cost and wide availability, PDW has the potential to be the tool that can predict AKI in extensive burn patients."

基金机构：Nantong Science and Technology Bureau [JC22022048]

基金资助正文：The authors would like to thank the medical and nursing teams in the center for contributing to the database. This work was supported by the Nantong Science and Technology Bureau (grant no. JC22022048).