Changing trends in the prevalence of heart failure impairment with Thalassemias over three decades

作者全名："Tang, Hongwei; Zhang, Nan; Deng, Jianchuan; Zhou, Kang"

作者地址："[Tang, Hongwei; Zhang, Nan; Deng, Jianchuan; Zhou, Kang] Chongqing Med Univ, Dept Hematol, Affiliated Hosp 2, Chongqing, Peoples R China; [Zhang, Nan] Wuhan Univ, Dept Hematol, Zhongnan Hosp, Wuhan, Peoples R China; [Deng, Jianchuan; Zhou, Kang] Chongqing Med Univ, Dept Hematol, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing, Peoples R China"

通信作者："Deng, JC; Zhou, K (通讯作者)，Chongqing Med Univ, Dept Hematol, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing, Peoples R China."

来源：EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001068192300001

JCR分区：Q1

影响因子：4.4

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：global burden of diseases; heart failure; prevalence; Thalassemias

摘要："BackgroundTo assess the prevalence trend and contributing factors of heart failure (HF) impairment with thalassemias at global, regional and national levels.MethodsData on HF impairment with thalassemias was collected from the Global Burden of Disease study. The absolute number and prevalence of the disease were systematically collected for each year, and the estimated annual percentage changes (EAPC) in HF impairment were calculated by gender, region and country to measure temporal trends.ResultsThalassemias have caused a significant global burden since 1990, and the case number of HF related to thalassemias has been steadily increasing. The highest case number of HF impairments with thalassemias is observed in China (7739 cases) and the highest prevalence is in Pakistan (1.61 per 100,000) currently. Besides, the middle sociodemographic index (SDI) region carries the highest burden of comorbid disease yet exhibits the most evident trend for improvement across the five regions (EAPC = -.98). The burden of thalassemias and comorbid HF is generally higher in males than females with the gender gap growing chasm in the future. Besides, the hotspots of HF impairment with thalassemias have gradually shifted to low SDI regions, though middle SDI regions still hold a relatively higher prevalence (.37 per 100,000) across different regions.ConclusionsThe burden of thalassemias and accompanying HF, as well as their temporal trends, vary greatly across countries and regions. These findings can improve understanding of these conditions and guide policymakers in developing appropriate policies to address disparities between countries. Prevalence trends of heart failure impairment with thalassemias.image"

基金机构：We thank the Global Burden of Disease Study Group for its long-standing collaboration.

基金资助正文：We thank the Global Burden of Disease Study Group for its long-standing collaboration.