Sprayed PAA-CaO₂ nanoparticles combined with calcium ions and reactive oxygen species for antibacterial and wound healing

作者全名："Yu, Hong; Sun, Jiale; She, Kepeng; Lv, Mingqi; Zhang, Yiqiao; Xiao, Yawen; Liu, Yangkun; Han, Changhao; Xu, Xinyue; Yang, Shuqing; Wang, Guixue; Zang, Guangchao"

作者地址："[Yu, Hong; Sun, Jiale; She, Kepeng; Lv, Mingqi; Zhang, Yiqiao; Xiao, Yawen; Liu, Yangkun; Han, Changhao; Xu, Xinyue; Zang, Guangchao] Chongqing Med Univ, Lab Teaching & Management Ctr, Tissue & Cell Biol, Chongqing 400016, Peoples R China; [Yang, Shuqing] Chongqing Univ Cent Hosp, Chongqing Emergency Med Ctr, Lab Tissue & Cell Biol, Chongqing 400030, Peoples R China; [Wang, Guixue; Zang, Guangchao] Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China; [Wang, Guixue; Zang, Guangchao] Jinfeng Lab, Chongqing 401329, Peoples R China"

通信作者："Zang, GC (通讯作者)，Chongqing Med Univ, Lab Teaching & Management Ctr, Tissue & Cell Biol, Chongqing 400016, Peoples R China.; Yang, SQ (通讯作者)，Chongqing Univ Cent Hosp, Chongqing Emergency Med Ctr, Lab Tissue & Cell Biol, Chongqing 400030, Peoples R China.; Wang, GX; Zang, GC (通讯作者)，Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China.; Wang, GX; Zang, GC (通讯作者)，Jinfeng Lab, Chongqing 401329, Peoples R China."

来源：REGENERATIVE BIOMATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001068212000001

JCR分区：Q1

影响因子：5.6

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：polyacrylic acid; calcium peroxide; nanomedicines; antibacterial; wound healing

摘要："The most common socioeconomic healthcare issues in clinical are burns, surgical incisions and other skin injuries. Skin lesion healing can be achieved with nanomedicines and other drug application techniques. This study developed a nano-spray based on cross-linked amorphous calcium peroxide (CaO2) nanoparticles of polyacrylic acid (PAA) for treating skin wounds (PAA-CaO2 nanoparticles). CaO2 serves as a 'drug' precursor, steadily and continuously releasing calcium ions (Ca2+) and hydrogen peroxide (H2O2) under mildly acidic conditions, while PAA-CaO2 nanoparticles exhibited good spray behavior in aqueous form. Tests demonstrated that PAA-CaO2 nanoparticles exhibited low cytotoxicity and allowed L929 cells proliferation and migration in vitro. The effectiveness of PAA-CaO2 nanoparticles in promoting wound healing and inhibiting bacterial growth in vivo was assessed in SD rats using full-thickness skin defect and Staphylococcus aureus (S.aureus)-infected wound models based thereon. The results revealed that PAA-CaO2 nanoparticles demonstrated significant advantages in both aspects. Notably, the infected rats' skin defects healed in 12 days. The benefits are linked to the functional role of Ca2+ coalesces with H2O2 as known antibacterial and healing-promoted agents. Therefore, we developed nanoscale PAA-CaO2 sprays to prevent bacterial development and heal skin lesions."

基金机构："Natural Science Foundation of Chongqing [31971242, 12032007]; National Natural Science Foundation of China [cstc2020jcyj-msxmX0330, cstc2021jsyj-yzysbA0057]; Science and Technology Innovation Project of Jinfeng Laboratory, Chongqing, China [jfkyjf202203001]; Project of Tutorial System of Medical Undergraduate in LabTeaching amp; Management Center in Chongqing Medical University [LTMCMTS202107]"

基金资助正文："This work was supported by grants from the Natural Science Foundation of Chongqing (cstc2020jcyj-msxmX0330, cstc2021jsyj-yzysbA0057); the National Natural Science Foundation of China(31971242, 12032007); the Science and Technology Innovation Project of Jinfeng Laboratory, Chongqing, China(jfkyjf202203001);the Project of Tutorial System of Medical Undergraduate in LabTeaching & amp; Management Center in Chongqing Medical University(LTMCMTS202107). We are also thankful for the First Batch of Key & nbsp;Disciplines on Public Health in Chongqing and the PublicExperiment Center of State Bioindustrial Base (Chongqing), China"