Smart Lubricant Coating with Urease-Responsive Antibacterial Functions for Ureteral Stents to Inhibit Infectious Encrustation

作者全名："Li, Kaijun; Tang, Haibin; Peng, Jinyu; Gao, Shuai; Du, Zongliang; Chen, Gang; Wu, Dimeng; Liu, Gongyan"

作者地址："[Li, Kaijun; Peng, Jinyu; Du, Zongliang; Liu, Gongyan] Sichuan Univ, Coll Biomass Sci & Engn, Chengdu 610065, Peoples R China; [Tang, Haibin; Chen, Gang] Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Gao, Shuai; Wu, Dimeng] Chengdu Daxan Innovat Med Tech Co Ltd, Chengdu 611135, Peoples R China"

通信作者："Liu, GY (通讯作者)，Sichuan Univ, Coll Biomass Sci & Engn, Chengdu 610065, Peoples R China.; Chen, G (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, 1 Youyi Rd, Chongqing 400016, Peoples R China.; Wu, DM (通讯作者)，Chengdu Daxan Innovat Med Tech Co Ltd, Chengdu 611135, Peoples R China."

来源：ADVANCED FUNCTIONAL MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001068420600001

JCR分区：Q1

影响因子：19

年份：2024

卷号：34

期号：2

开始页：　

结束页：　

文献类型：Article

关键词：hydrophilic lubricant coatings; smart antibacterial; urease-responsive on-demand antibiotic release; ureteral stents

摘要："Hydrophilic lubricant coatings with antifouling properties are commercially applied to urological devices, such as ureteral stents (USs), to inhibit biofilm formation and reduce the likelihood of infectious encrustation. However, their long-term effectiveness is limited due to the lack of active and precise antibacterial activity. Herein, this work reports a hydrophilic lubricant (defined as SA-PU/PVP) coating with smart urease-responsive antibiotic release functionality, achieved by incorporating the antibiotic sulfanilamide-conjugated polyurethane (SA-PU) polymers into a commercial lubricant coating agent containing hydrophilic polyvinylpyrrolidone (PVP). During the initial implantation period, the hydrophilic PVP chains rapidly absorb urine on the coating interface, forming a lubricating layer with the desired antifouling activities that reduce the attachment of host proteins, bacteria, and urate crystals by over 90%. As time progresses and the bacteria proliferates and produces urease, the urease enzymatically degrades the urea linkages in the SA-PU/PVP coating, actively releasing SA antibiotics on demand to prevent biofilm formation and encrustation. Benefiting from this synergistic antifouling and smart antibacterial activities, the SA-PU/PVP-coated US exhibits superior performance in preventing infectious encrustation in a porcine model over a 7-week period, surpassing the effectiveness of a commercial hydrophilic lubricant US. This coating strategy offers a practical solution for inhibiting urological device-associated complications. This work reports a hydrophilic lubricant coating with smart urease-responsive antibiotic release functionality, achieved by incorporating the antibiotic sulfanilamide-conjugated polyurethane polymers into a commercial lubricant coating agent containing hydrophilic polyvinylpyrrolidone. This simple yet practical engineering strategy significantly enhances the long-term anti-biofilm and anti-encrustation capabilities of ureteral stents, with an implantation period of more than 7 weeks.image"

基金机构："National Key Research and Development Program of China [2020YFC1107301, 2020YFC1107300]; Sichuan University-Dazhou City [2021CDDZ-21]; Chengdu Science and Technology Bureau [2022-YF05-01523-SN]"

基金资助正文："This work was supported by the National Key Research and Development Program of China (grant numbers 2020YFC1107301 and 2020YFC1107300); the Sichuan University-Dazhou City (grant number 2021CDDZ-21); the Chengdu Science and Technology Bureau (2022-YF05-01523-SN). Thanks for Dr. Hui Wang (Pub-Lab Platform, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University) for her invaluable assistance with ATR-FTIR."