Bioinspired poly(aspartic acid) based hydrogel with ROS scavenging ability as mEGF carrier for wound repairing applications

作者全名："Zhang, Kaiyue; Yin, Liping; Jia, Boyang; Wang, Yong; Li, Wenjuan; Yu, Xian; Qin, Jianglei"

作者地址："[Zhang, Kaiyue; Yin, Liping; Jia, Boyang; Qin, Jianglei] Hebei Univ, Coll Chem & Mat Sci, Baoding 071002, Hebei, Peoples R China; [Wang, Yong; Li, Wenjuan; Qin, Jianglei] Hebei Univ, Key Lab Pathogenesis Mech & Control Inflammatory A, Baoding 071002, Hebei, Peoples R China; [Yu, Xian] Chongqing Med Univ, Affiliated Hosp 2, Phase I Clin Trial Ctr, Chongqing, Peoples R China"

通信作者："Qin, JL (通讯作者)，Hebei Univ, Coll Chem & Mat Sci, Baoding 071002, Hebei, Peoples R China.; Yu, X (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Phase I Clin Trial Ctr, Chongqing, Peoples R China."

来源：COLLOIDS AND SURFACES B-BIOINTERFACES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001069181700001

JCR分区：Q1

影响因子：5.4

年份：2023

卷号：230

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Poly(aspartic acid); Self-healing hydrogel; Skin adhesion; Hemostasis; Wound repairing

摘要："Poly(amino acid) based self-healing hydrogels have important application in biomedications. In this research, the catechol pendant groups were imported to poly(aspartic acid) based self-healing hydrogel to improved skin adhesion and ROS scavenging performance. The poly(succinimide) (PSI) was reacted with 3,4-dihydroxyphenylalanine (DA) and then hydraziolyzed to import catechol group and hydrazide group respectively, which are responsible for mussel inspired tissue adhesion and dynamic coupling reactivity. The dopamine modified poly (aspartic hydrazide) (PDAH) was reacted with PEO90 dialdehyde (PEO90 DA) to prepare hydrogels, and the resultant hydrogel showed good biocompatibility both in vitro and in vivo. The skin adhesion strength of the mussel inspired hydrogel increased notably with enhanced radical scavenging efficiency fit for in vivo wound repairing applications. The PDAH/PEO90 DA hydrogel also showed sustained albumin release profile and the in vivo wound repairing experiment proved the mouse Epidermal Growth Factor (mEGF) loaded hydrogel as wound dressing material accelerated the wound repairing rate."

基金机构："National Natural Science Foundation of China [82072327]; Natural Science Interdisciplinary Research Program of Hebei University [DXK202202]; Medical Science Foundation of Hebei University [2021A01, 2021 x 01]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (82072327) , Natural Science Interdisciplinary Research Program of Hebei University (DXK202202) and Medical Science Foundation of Hebei University (2021A01, 2021 x 01) ."