The effect of GelDex-S58 hydrogel on anti-conjunctival scarring after glaucoma filtration surgery

作者全名："Lin, Yi; Luo, Wangdu; Jiang, Bingcai; Lin, Qianyi; Tang, Min; Li, Xiangji; Xie, Lin"

作者地址："[Lin, Yi; Luo, Wangdu; Jiang, Bingcai; Lin, Qianyi; Tang, Min; Li, Xiangji; Xie, Lin] Chongqing Med Univ, Affiliated Hosp 3, Dept Ophthalmol, Chongqing, Peoples R China"

通信作者："Xie, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 3, Dept Ophthalmol, Chongqing, Peoples R China."

来源：ISCIENCE

ESI学科分类：　

WOS号：WOS:001070331100001

JCR分区：Q1

影响因子：4.6

年份：2023

卷号：26

期号：9

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Excessive scarring is the main cause of surgical failure in glaucoma filtration surgery. S58 has been shown to have an excellent antifibrotic effect but its duration of action is not sufficient to achieve the desired anti-scarring effect. In this study, a light-cured bioadhesive hydrogel composed of GelMA and oxidized dextran (ODex), namely, GelDex, was used to load S58 (GelDex-S58). The microscopic morphology of GelDex-S58 appeared to be a porous structure with good slow-release properties and suitable degradation time. Cell Counting Kit-8, cell scratch and transwell assays showed that GelDex-S58 significantly reduced TGF-beta-induced fibroblast proliferation, increased migration and invasion ability. In in vivo studies, GelDex-S58 treatment prolonged follicular retention, reduced mean intraocular pressure, and significantly reduced collagen deposition and alpha-SMA expression levels in the conjunctival tissue compared to treatment with S58 alone. In conclusion, GelDex-S58 could reduce scar formation after glaucoma filtration surgery."

基金机构："National Natural Science Foundation of China [81470629, 81670860]; Chongqing Natural Research Foundation [cstc 2018jcyjAX0034]; Senior Medical Talents Program of Chongqing for Youngand Middleaged"

基金资助正文："The research work was supported by the National Natural Science Foundation of China (Grant no. 81470629 and 81670860; Chongqing, China) , Chongqing Natural Research Foundation (No. cstc 2018jcyjAX0034; Chongqing, China) , Senior Medical Talents Program of Chongqing for Youngand Middleaged."