Global burden of neoplasms attributable to specific occupational carcinogens over 30 years: a population-based study

作者全名："Qu, C.; He, R.; Hou, W.; Ye, W.; Cao, H.; Zhang, H.; Zhang, N.; Cheng, Q.; Zhang, Q.; Luo, P."

作者地址："[Qu, C.; He, R.; Hou, W.; Ye, W.; Zhang, H.; Cheng, Q.] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Hunan, Peoples R China; [Qu, C.; He, R.; Hou, W.; Ye, W.; Cheng, Q.] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China; [Qu, C.; He, R.; Hou, W.] Cent South Univ, Xiangya Sch Med, Changsha, Hunan, Peoples R China; [Cao, H.] Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Dept Psychiat, Changsha, Hunan, Peoples R China; [Zhang, H.] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing, Peoples R China; [Zhang, N.] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan, Hubei, Peoples R China; [Zhang, Q.] Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Inst Digest Dis, Sch Med,NHC Key Lab Digest Dis,Div Gastroenterol &, Shanghai, Peoples R China; [Luo, P.] Southern Med Univ, Zhujiang Hosp, Dept Oncol, Guangzhou, Guangdong, Peoples R China; [Luo, P.] Southern Med Univ, Zhujiang Hosp, Dept Oncol, Guangzhou, Peoples R China"

通信作者："Cheng, Q (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Hunan, Peoples R China.; Zhang, Q (通讯作者)，Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Inst Digest Dis, Sch Med,NHC Key Lab Digest Dis,Div Gastroenterol &, Shanghai, Peoples R China.; Luo, P (通讯作者)，Southern Med Univ, Zhujiang Hosp, Dept Oncol, Guangzhou, Peoples R China."

来源：PUBLIC HEALTH

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:001070511000001

JCR分区：Q1

影响因子：3.9

年份：2023

卷号：223

期号：　

开始页：145

结束页：155

文献类型：Article

关键词：Neoplasms; Mortality; DALYs; Age-period-cohort; Occupational carcinogens

摘要："Objectives: The study aimed to analyze the global burden of occupational neoplasms from various epidemiological perspectives. Study design: In this cross-sectional study, secondary analyses were conducted to assess the burden of neoplasms attributable to occupational carcinogens and their distribution characteristics using data from GBD 2019 and the World Bank database.Methods: Based on the GBD 2019 and the World Bank database, we analyzed the global burden of occupational neoplasms including the age-period-cohort model, decomposition analysis, health inequality analysis, and panel model. All analyses were conducted in R (version 4.0.3) and Joinpoint (version 4.9.1).Results: The absolute number of neoplasms burden attributable to occupational carcinogens has continued to rise over 30 years. In 2019, occupational neoplasms caused 333,867 [95% uncertainty interval (UI): 263,491 to 404,641] mortalities and 6,964,775 (95% UI: 5,467,884 to 8,580,431) disabilityadjusted life years (DALYs) globally. Greenland, Monaco, the Netherlands, and Andorra suffered the highest burden. The burden was higher in countries with a higher sociodemographic index. The age effect was prominent in the elderly, and the 1925 birth cohort had the highest cohort effect. Population growth was the most significant driver of the mortalities (89%) and DALYs (111%) change. Moreover, the proportion of urban population was significantly positively associated with the disease burden, while GDP per capita was negatively correlated with the disease burden.Conclusions: The burden of occupational neoplasms was unevenly distributed across locations and populations. The need for rational allocation of healthcare resources was urgent.& COPY; 2023 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved."

基金机构：Hunan Provincial Natural Sci-ence Foundation of China [2022JJ20 095]; Hunan Provincial Health Committee Foundation of China [202204044869]

基金资助正文：Funding This research was supported by Hunan Provincial Natural Sci-ence Foundation of China (NO.2022JJ20 095) and Hunan Provincial Health Committee Foundation of China (NO.202204044869) .