Effects of BCG-PSN on the Levels of Inflammatory Factors and Th1/Th2 Differentiation in Chronic Spontaneous Urticaria: Meta-Analysis and Systematic Review

作者全名："Fu, Qiang; Huang, Fu-Jun; Zhou, Zi-Wenyan; Tang, Lei; Zheng, Qi; Zhang, Miao; Zhou, Xun"

作者地址："[Fu, Qiang; Huang, Fu-Jun; Tang, Lei; Zheng, Qi; Zhou, Xun] Chongqing Hosp Tradit Chinese Med, Dept Dermatol & Cosmetol, Chongqing 400000, Peoples R China; [Huang, Fu-Jun; Zhang, Miao; Zhou, Xun] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400000, Peoples R China; [Zhou, Zi-Wenyan] Chongqing Med Univ, Chongqing 400000, Peoples R China"

通信作者："Zhou, X (通讯作者)，Chongqing Hosp Tradit Chinese Med, Dept Dermatol & Cosmetol, Chongqing 400000, Peoples R China.; Zhou, X (通讯作者)，Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400000, Peoples R China."

来源：DERMATOLOGIC THERAPY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001070685700001

JCR分区：Q1

影响因子：3.7

年份：2023

卷号：2023

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：　

摘要："Background. Bacillus Calmette-Guerin polysaccharide nucleic acid (BCG-PSN), as an immune modulator, can effectively regulate the immune function of the body, control the release of histamine inflammatory substances, and achieve allergic effects against chronic spontaneous urticaria (CSU). This study aimed to evaluate the effectiveness of BCG-PSN on the levels of inflammatory factors and Th1/Th2 differentiation in CSU.Methods. A systemic literature search of BCG-PSN treatment of CSU was performed using the PubMed, Cochrane Library, Web of Science, CBM, and other databases. A quantitative meta-analysis was conducted according to the guidelines of the Cochrane Handbook. Review manager software 5.4 was used for meta-analysis.Results. Twenty-seven studies pertaining to 2840 patients were included. The duration of treatment was 4 to 12 weeks. BCG-PSN can increase CD3+T levels (MD = 6.06; 95% CI: 5.30 to 6.82; p < 0.00001; I-2 = 31%), CD4+T levels (MD = 5.41; 95% CI: 4.82 to 6.01; p < 0.00001; I-2 = 40%), and CD4+/CD8+(MD = 0.33; 95% CI: 0.28 to 0.38; p < 0.00001; I-2 = 15%); at the same time, BCG-PSN can downregulate CD8+T levels (MD = -3.28; 95% CI: -3.82 to -2.74; p < 0.00001; I-2= 32%). Furthermore, BCG-PSN could downregulate IL-4 levels (MD = -4.06, 95% CI: -5.15 to -2.97, p < 0.00001; I-2 = 0%), TNF-a levels (MD = -2.34; 95% CI: -3.01 to -1.66; p < 0.00001; I-2 = 26%) and upregulate IL-10 levels (MD = 25.59, 95% CI: 23.50 to 27.69, p < 0.00001; I-2 = 0%) and INF-? levels (MD = 4.62, 95% CI: 3.79 to 5.45, p < 0.00001; I-2 = 5%).Conclusions. BCG-PSN can regulate the levels of inflammatory factors and Th1/Th2 differentiation in CSU. However, the long-term effectiveness and more objective experimental indicators of BCG-PSN remain to be further studied."

基金机构："This work was supported by the Chongqing City Science and Technology Plan Project (Grant no. 2021ZY023609), Chongqing Municipal Health Commission (Grant no. CQYC20200303138), and Jiangbei District of Chongqing Science and Health Joint Medical Research Proj [2021ZY023609]; Chongqing City Science and Technology Plan Project [CQYC20200303138]; Chongqing Municipal Health Commission; Jiangbei District of Chongqing Science and Health Joint Medical Research Project"

基金资助正文："This work was supported by the Chongqing City Science and Technology Plan Project (Grant no. 2021ZY023609), Chongqing Municipal Health Commission (Grant no. CQYC20200303138), and Jiangbei District of Chongqing Science and Health Joint Medical Research Project."