Correlation of Nonalcoholic Fatty Liver Disease with Dietary Folate and Serum Folate in US Adults: Cross-Sectional Analyses from National Health and Nutrition Examination Survey 2009-2018

作者全名："Chen, Yushi; Xiang, Ling; Luo, Ling; Qin, Haixia; Tong, Shiwen"

作者地址："[Chen, Yushi; Xiang, Ling; Luo, Ling; Qin, Haixia; Tong, Shiwen] Chongqing Med Univ, Affiliated Hosp 2, Dept Clin Nutr, Chongqing, Peoples R China; [Tong, Shiwen] Chongqing Med Univ, Affiliated Hosp 2, Dept Clin Nutr, 76 Linjiang Rd, Chongqing 400000, Peoples R China"

通信作者："Tong, SW (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Clin Nutr, 76 Linjiang Rd, Chongqing 400000, Peoples R China."

来源：METABOLIC SYNDROME AND RELATED DISORDERS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001071483100005

JCR分区：Q4

影响因子：1.3

年份：2023

卷号：21

期号：7

开始页：389

结束页：396

文献类型：Article

关键词：nutrition; non-alcoholic fatty liver disease; folate; folic acid

摘要："Background and Aims: Nonalcoholic fatty liver disease (NAFLD) is a global health problem, and dietary intervention is still considered one of the primary interventions. This study aimed to examine cross-sectional associations between dietary and serum levels of folate and NAFLD. Methods: We conducted a study of 7543 adults who participated in the National Health and Nutrition Examination Survey, 2009-2018. NAFLD status was determined by a fatty liver index (FLI) value >= 60. Multivariable logistic regression models were used to estimate associations between folate and NAFLD. Results: Almost half (45%) of the patients were classified as having NAFLD based on the FLI. In the fully adjusted model, participants in the highest quartile of dietary total folate and food folate were found to have a lower prevalence of NAFLD than those in the lowest quartile [odds ratio (OR) (quartile) (4 versus) 1 = 0.582; 95% confidence interval (CI) = 0.350-0.968; and ORquartile 4 versus 1 = 0.737; 95% CI = 0.611-0.888, respectively], and the fourth quartile values of serum total folate and 5-methyl-tetrahydrofolate were significantly negatively associated with NAFLD prevalence (ORquartile 4 versus 1 = 0.664; 95% CI = 0.495-0.891; and ORquartile 4 versus 1 = 0.712; 95% CI = 0.532-0.954, respectively). Subgroup analyses revealed that this beneficial association was more significant in women (ORquartile 4 versus 1 = 0.526; 95% CI = 0.329-0.843; p(interaction) < 0.001) than in men (ORquartile 4 versus 1 = 0.805; 95% CI = 0.546-1.186). Conclusions: Higher dietary folate intake and serum folate levels are associated with a lower NAFLD prevalence among U.S. adults and the trend is more pronounced among women, indicating opportunities for dietary NAFLD interventions."

基金机构："Natural Science Foundation of Chongqing, China [cstc2019jcyj-msxmX0863]; Program for Outstanding Young Talent of Chongqing Kuanren Hospital"

基金资助正文："This study was funded by the Natural Science Foundation of Chongqing, China (cstc2019jcyj-msxmX0863), and the Program for Outstanding Young Talent of Chongqing Kuanren Hospital."