Azvudine and mortality in patients with coronavirus disease 2019: A retrospective cohort study

作者全名："Liu, Bin; Yang, Mingjin; Xu, Li; Li, Yishi; Cai, Jing; Xie, Bo; Zong, Kaican; Guo, Shuliang"

作者地址："[Liu, Bin; Yang, Mingjin; Xu, Li; Li, Yishi; Xie, Bo; Zong, Kaican; Guo, Shuliang] Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Youyi Rd 1, Chongqing 400016, Peoples R China; [Liu, Bin; Xie, Bo] Cent South Univ, Zhuzhou Cent Hosp, Zhuzhou Hosp, Dept Resp & Crit Care Med,Xiangya Sch Med, 116, Changjiang South Rd, Zhuzhou 412007, Hunan, Peoples R China; [Cai, Jing] Chengdu First Peoples Hosp, Dept Endocrinol & Metab, 18 Wanxiang North Rd, Chengdu 610000, Sichuan, Peoples R China"

通信作者："Guo, SL (通讯作者)，Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Youyi Rd 1, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL IMMUNOPHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001072002700001

JCR分区：Q1

影响因子：4.8

年份：2023

卷号：124

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：FNC; COVID-19; Mortality; Severe

摘要："Objectives: Several studies have found that azvudine (FNC) can inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication both in vivo and in vitro. However, the effect of FNC on the risk of death in patients with coronavirus disease 2019 (COVID-19) is unclear. This study aims to investigate the effect of FNC on the risk of death in patients with coronavirus disease 2019 (COVID-19).Methods: Charts of consecutive patients hospitalized at five hospitals in Chongqing with confirmed COVID-19. The primary outcome of the study was 28-day mortality. Secondary outcomes were: ICU admission rates, length of hospital and ICU stay, and also the range of mechanical ventilation days when admission. We compared primary outcome in patients who received FNC with those in patients who did not, using a multivariable model with inverse probability weighting according to the propensity score.Results: We included 1,110 patients in our study cohort. Of the 236 patients treated with FNC, 30 died within 28 days (12.7%), and of the 874 patients not treated with FNC, 206 died within 28 days (23.6%). In the crude, unadjusted analysis, a significant beneficial effect of FNC in terms of the 28-day mortality (OR 0.472, 95% CI 0.312-0.714; p < 0.001) in the overall population was detected. The adjusted odds ratio by multivariate analysis was (OR 0.498, 95% CI 0.287-0.864; p = 0.013). In the multivariate analysis with inverse probability weighting according to the propensity score, a significantly beneficial effect of FNC in terms of the 28-day mortality was further confirmed (OR 0.754, 95% CI 0.614-0.925; p = 0.007). Moreover, multivariable propensity-score analyses with matching also yielded similar results (OR 0.438, 95% CI 0.246-0.778; p = 0.005).Conclusion: Our results reveal that in patients with COVID-19, FNC administration was associated with a significantly reduced 28-day mortality."

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